Jonathan A Leighton1, Debra J Helper2, Ian M Gralnek3, Iris Dotan4, Ignacio Fernandez-Urien5, Adi Lahat6, Pramod Malik7, Gerard E Mullin8, Bruno Rosa9. 1. Mayo Clinic Arizona, Scottsdale, Arizona, USA. 2. Indiana University School of Medicine, Indianapolis, Indiana, USA. 3. Institute of Gastroenterology and Liver Diseases, Ha'Emek Medical Center, Afula, Israel. 4. IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, and the Sackler Faculty of Medicine, Tel Aviv, Israel. 5. Hospital de Navarra, Navarra, Spain. 6. Department of Gastroenterology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 7. Gastrointestinal and Liver Specialists of Tidewater, Suffolk, Virginia, USA. 8. The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 9. Gastroenterology Department, Centro Hospitalar do Alto Ave, Guimarães, Portugal.
Abstract
BACKGROUND AND AIMS: Crohn's disease (CD) is typically diagnosed with ileocolonoscopy (IC); however, when inflammation is localized solely in the small bowel, visualization of the entire small-bowel mucosa can be challenging. The aim of this study was to compare the diagnostic yield of a pan-enteric video capsule endoscope (small-bowel colon [SBC] capsule) versus IC in patients with active CD. METHODS: This was a prospective, multicenter study. Patients with known active CD and proven bowel luminal patency underwent a standardized colon cleansing protocol followed by ingestion of the capsule. After passage of the capsule, IC was performed and recorded. Lesions indicative of active CD were assessed. RESULTS: One hundred fourteen subjects were screened; 66 subjects completed both endoscopic procedures. The per-subject diagnostic yield rate for active CD lesions was 83.3% for SBC and 69.7% for IC (yield difference, 13.6%; 95% confidence interval [CI], 2.6%-24.7%); 65% of subjects had active CD lesions identified by both modalities. Of the 12 subjects who were positive for active CD by SBC only, 5 subjects were found to have active CD lesions in the terminal ileum. Three subjects were positive for active CD by IC only. Three hundred fifty-five classifying bowel segments were analyzed; the per-segment diagnostic yield rate was 40.6% for SBC and 32.7% for IC (yield difference 7.9%; 95% CI, 3.3%-12.4%). CONCLUSION: This preliminary study shows that the diagnostic yields for SBC might be higher than IC; however, the magnitude of difference between the two is difficult to estimate. Further study is needed to confirm these findings.
BACKGROUND AND AIMS: Crohn's disease (CD) is typically diagnosed with ileocolonoscopy (IC); however, when inflammation is localized solely in the small bowel, visualization of the entire small-bowel mucosa can be challenging. The aim of this study was to compare the diagnostic yield of a pan-enteric video capsule endoscope (small-bowel colon [SBC] capsule) versus IC in patients with active CD. METHODS: This was a prospective, multicenter study. Patients with known active CD and proven bowel luminal patency underwent a standardized colon cleansing protocol followed by ingestion of the capsule. After passage of the capsule, IC was performed and recorded. Lesions indicative of active CD were assessed. RESULTS: One hundred fourteen subjects were screened; 66 subjects completed both endoscopic procedures. The per-subject diagnostic yield rate for active CD lesions was 83.3% for SBC and 69.7% for IC (yield difference, 13.6%; 95% confidence interval [CI], 2.6%-24.7%); 65% of subjects had active CD lesions identified by both modalities. Of the 12 subjects who were positive for active CD by SBC only, 5 subjects were found to have active CD lesions in the terminal ileum. Three subjects were positive for active CD by IC only. Three hundred fifty-five classifying bowel segments were analyzed; the per-segment diagnostic yield rate was 40.6% for SBC and 32.7% for IC (yield difference 7.9%; 95% CI, 3.3%-12.4%). CONCLUSION: This preliminary study shows that the diagnostic yields for SBC might be higher than IC; however, the magnitude of difference between the two is difficult to estimate. Further study is needed to confirm these findings.
Authors: Foong Way D Tai; Pierre Ellul; Alfonso Elosua; Ignacio Fernandez-Urien; Gian E Tontini; Luca Elli; Rami Eliakim; Uri Kopylov; Sara Koo; Clare Parker; Simon Panter; Reena Sidhu; Mark McAlindon Journal: United European Gastroenterol J Date: 2021-03-19 Impact factor: 4.623