| Literature DB >> 27658369 |
Xiaohu Deng1, Siquan Sun1, Jiejun Wu1, Chester Kuei1, Victory Joseph1, Changlu Liu1, Neelakandha S Mani2.
Abstract
Synthesis of several 7-hydroxy oxysterols and their potential roles as signaling molecules in the innate and adaptive immune responses is discussed. Discovery of a new, fluorinated, synthetic analog of the 7α,25-dihydroxycholesterol-the endogenous ligand of GPR 183 (EBI2), a G-protein coupled receptor highly expressed upon Epstein-Barr virus infection is described. Fluoro oxysterol 12 showed good metabolic stability while maintaining excellent EBI2 agonist activity.Entities:
Keywords: EBI2 agonist; Epstein–Barr virus; Fluoro oxysterol; GPR 183; Immune response; Oxysterols
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Year: 2016 PMID： 27658369 DOI： 10.1016/j.bmcl.2016.09.029
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823