Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.

[This corrects the article DOI: 10.1371/journal.pone.0160350.].

There is an error in the third-to-last sentence of the “BmMetRS in complex with inhibitors” section. The correct sentence is: A superposition of 4PY2 Chain B and 4MVW Chain A gives a good illustration of this (Fig 7).

Fig 7

A superposition of BmMetRS (PDB ID 4PY2 Chain B) and TbMetRS (PDB ID 4MVW Chain) bound to compound 1433.

A key difference is the interaction of BmMetRS Phe213 which is functionally equivalent to Leu456 in TbMetRS but led to different protein geometry. The TbMetRS structure is shown in blue and the 2 different residues in orange.

There is an error in the caption for Fig 7. Please see the correct Fig 7 caption here.

Additionally, in Table 2, the “PDB code” value for “1433” should read “4PY2”. Please view the corrected Table 2 here.

Table 2

Data collection and model refinement statistics.

Crystal	SeMet	1312	1415	1433
PDB code	4DLP	5K0S	5K0T	4PY2
Data collection
Space Group	P 1 21 1	P 1	P 1	P 1
Cell dimensions
a, b, c (Å)	116.25, 77.62, 116.27	45.27, 99.74, 104.63	45.16, 99.65, 104.30	45.01, 99.48, 104.00
Α, β, γ (°)	90, 119.67, 90	110.58, 87.63, 99.91	110.46, 88.09, 99.72	110.47, 87.24, 99.99
Resolution range (Å)	50.00–2.65 (2.72–2.65)	50.00–2.40 (2.46–2.40)	50.00–2.60 (2.67–2.60)	50.00–2.15 (2.21–2.15)
No. of unique reflections	52379	63652	49660	88924
Rmerge (%)a	7.1 (48.6)	6.4 (52.5)	7.5 (47.0)	6.6 (53.6)
Redudancy a	3.7 (3.7)	2.4 (2.4)	2.4 (2.4)	3.9 (4.0)
Completeness (%)a	99.3 (99.5)	96.3 (85.2)	96.0 (97.5)	98.2 (97.3)
l/σIa	15.21 (2.63)	11.43 (2.13)	10.12 (2.07)	15.76 (2.73)
Refinement
Resolution range	50.00–2.65 (2.72–2.65)	50.00–2.40 (2.46–2.40)	50.00–2.60 (2.67–2.60)	50.00–2.15 (2.21–2.15)
No. of protein atoms	10934	11469	11189	11480
No. of water molecules	88	219	169	135
Rcryst (%)	19.7	21.0	25.6	17.8
Rfree (%)	23.7	25.6	28.6	21.1
Root-mean-square deviations from ideal stereochemistry
Bond lengths (Å)	0.012	0.003	0.008	0.011
Bond angles (°)	1.421	0.577	1.183	1.384
Mean B factor (all atoms) (Å2)	48.25	43.29	49.76	35.98
Ramachandran plot
Favored region (%)	96.87	98.77	98.67	97.43
Allowed regions (%)	3.13	1.23	1.33	2.57
Outlier regions (%)	0.00	0.00	0.00	0.00
Clashscore	2.3	2.5	0.46	0.79
Molprobity Score	1.18	1.15	0.74	0.75