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Literature DB >> 27657445

Deeper Insights into the Allosteric Modulation of Ionotropic Glutamate Receptors.

Abstract

Two articles in this issue of Neuron (Yelshanskaya et al., 2016; Yi et al., 2016) explore the structural basis of allosteric inhibition in ionotropic glutamate receptors, providing key insights into how iGluRs function in the brain as well as how they might be pharmacologically modulated in neurological disorders and disease.

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Year: 2016 PMID： 27657445 PMCID： PMC5279892 DOI： 10.1016/j.neuron.2016.09.013

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

11 in total

Review 1. Glutamate receptor ion channels: structure, regulation, and function.

Authors: Stephen F Traynelis; Lonnie P Wollmuth; Chris J McBain; Frank S Menniti; Katie M Vance; Kevin K Ogden; Kasper B Hansen; Hongjie Yuan; Scott J Myers; Ray Dingledine
Journal: Pharmacol Rev Date: 2010-09 Impact factor: 25.468

2. Molecular mechanism of AMPA receptor noncompetitive antagonism.

Authors: Victoria Balannik; Frank S Menniti; Ana V Paternain; Juan Lerma; Yael Stern-Bach
Journal: Neuron Date: 2005-10-20 Impact factor: 17.173

3. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.

Authors: Ezio Bettini; Anna Sava; Cristiana Griffante; Corrado Carignani; Alberto Buson; Anna Maria Capelli; Michele Negri; Filippo Andreetta; Sergio A Senar-Sancho; Lorena Guiral; Francesca Cardullo
Journal: J Pharmacol Exp Ther Date: 2010-09-01 Impact factor: 4.030

1. Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders.

Authors: Simone Brogi; Giuseppe Campiani; Margherita Brindisi; Stefania Butini
Journal: ACS Med Chem Lett Date: 2019-01-23 Impact factor: 4.345

1 in total

Deeper Insights into the Allosteric Modulation of Ionotropic Glutamate Receptors.

Review 1. Glutamate receptor ion channels: structure, regulation, and function.

2. Molecular mechanism of AMPA receptor noncompetitive antagonism.

3. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.

4. Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.

5. Structural insights into competitive antagonism in NMDA receptors.

Review 6. A structural biology perspective on NMDA receptor pharmacology and function.

7. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.

8. Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.

9. Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.

10. Crystal structure of a heterotetrameric NMDA receptor ion channel.

1. Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders.