| Literature DB >> 2765708 |
D W Nitzan1, A T Horowitz, D Darmon, M M Friedlaender, D Rubinger, P Stein, I Bab, M M Popovtzer, J Silver.
Abstract
A case of oncogenous osteomalacia due to a fibrosarcoma of the maxilla is reported, with a 19 year course before treatment. Metabolic studies of calcium and phosphorus were performed 3 and 19 years after the first symptomology. There was a negative balance for both phosphorus and calcium with low serum levels of 1,25-dihydroxyvitamin D which were corrected by resection of the tumor. Portions of the tumor were cultured and the supernatant did not affect phosphorus transport by a proximal tubule kidney cell line. Other portions were injected into athymic nude mice where they resulted in hypophosphatemia and phosphaturia, thus confirming the endocrine nature of the oncogenous osteomalacia factor.Entities:
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Year: 1989 PMID： 2765708 DOI： 10.1016/0169-6009(89)90050-0
Source DB: PubMed Journal: Bone Miner ISSN： 0169-6009