Mayuri Jain1. 1. Senior Lecturer, Department of Oral Medicine and Radiology, Maharana Pratap College of Dentistry & Research Centre , Putli Ghar Road, Gwalior (M.P), India .
Abstract
INTRODUCTION: Most common malignant neoplasm in the oral cavity is squamous cell carcinoma. Herpes simplex virus (HSV) may enhance the development of oral carcinoma in individuals who are already at increased risk of the disease because of tobacco consumption and cigarette smoking and so must be considered as a possible etiologic agent in oral cancer and precancer. AIM: To assess and compare the correlation of HSV-1 in oral cancer and precancerous lesions/conditions with healthy subjects. MATERIALS AND METHODS: The study comprised of 150 subjects who were divided into three groups as oral cancer, precancer and control group. Their blood samples were collected and were tested for HSV-1 IgG antibody level, using 'Herpe Select-1' ELISA kit. RESULTS: There was statistically insignificant difference between the HSV-1 IgG level in cancer and precancer but statistically significant difference was found between the HSV-1 IgG level among control group and cancer/precancer. CONCLUSION: The present study clearly indicates that quantitative estimation of IgG antibody against HSV-1 in cancer/precancer patients will give the clue in the etiology of cancer or precancer. However, further studies with a large sample size should be carried out to determine the role of HSV-1 in etiology of oral cancer and precancer.
INTRODUCTION: Most common malignant neoplasm in the oral cavity is squamous cell carcinoma. Herpes simplex virus (HSV) may enhance the development of oral carcinoma in individuals who are already at increased risk of the disease because of tobacco consumption and cigarette smoking and so must be considered as a possible etiologic agent in oral cancer and precancer. AIM: To assess and compare the correlation of HSV-1 in oral cancer and precancerous lesions/conditions with healthy subjects. MATERIALS AND METHODS: The study comprised of 150 subjects who were divided into three groups as oral cancer, precancer and control group. Their blood samples were collected and were tested for HSV-1 IgG antibody level, using 'Herpe Select-1' ELISA kit. RESULTS: There was statistically insignificant difference between the HSV-1 IgG level in cancer and precancer but statistically significant difference was found between the HSV-1 IgG level among control group and cancer/precancer. CONCLUSION: The present study clearly indicates that quantitative estimation of IgG antibody against HSV-1 in cancer/precancer patients will give the clue in the etiology of cancer or precancer. However, further studies with a large sample size should be carried out to determine the role of HSV-1 in etiology of oral cancer and precancer.
Authors: Jamshid Jalouli; Salah O Ibrahim; Ravi Mehrotra; Miranda M Jalouli; Dipak Sapkota; Per-Anders Larsson; Jan-M Hirsch Journal: Acta Otolaryngol Date: 2010-11 Impact factor: 1.494
Authors: J R Starr; J R Daling; E D Fitzgibbons; M M Madeleine; R Ashley; D A Galloway; S M Schwartz Journal: Cancer Res Date: 2001-12-01 Impact factor: 12.701