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Literature DB >> 27656491

Cefoperazone Induced Gastrointestinal Bleeding.

Goutham Reddy Katukuri¹, Raja Naga Mahesh Maddala¹, Kusugodlu Ramamoorthi², Manjunatha Hande³.

Abstract

Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. We report a case of cefoperazone induced coagulopathy manifesting as gastrointestinal bleeding. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient's coagulation function disorder and her use of the suspect drug.

Entities: Chemical Disease Species

Keywords: Cefoperazone; Coagulopathy; Vitamin K

Year: 2016 PMID： 27656491 PMCID： PMC5028500 DOI： 10.7860/JCDR/2016/19694.8316

Source DB: PubMed Journal: J Clin Diagn Res ISSN： 0973-709X

12 in total

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Authors: I O Ozen; S Moralioğlu; R Karabulut; B Bagbanci; Z Turkyilmaz; B Demirogullari; K Sonmez; A C Basaklar; N Kale
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Authors: ZhuYing Cai; Wei Yang; YingYing He; Qingge Chen; ShiQiang Wang; Xuming Luo; Xiongbiao Wang
Journal: Drug Saf Case Rep Date: 2016-12

3 in total