Literature DB >> 27656454

Incidental Detection of Hairy Cell Leukaemia with Herpes Simplex Virus (HSV) Related Lip Ulcer Mimicking Carcinoma.

Pallavi Agrawal1, Richa Bhartiya2, Ran Vijoy Narayan Singh3.   

Abstract

Hairy cell leukemia is a chronic lympho-proliferative disease. It is indolent but progressive in nature. It arises from B-cell lineage. We report an incidentally detected case of Hairy Cell Leukaemia (HCL) in a 55-year-old male patient with Herpes simplex virus (HSV) - related lip ulcer mimicking squamous cell carcinoma. Clinically the patient presented with lip ulceration without pain. He was found to have moderate hepatosplenomegaly and pancytopenia on general examination. Bone marrow aspiration and flow cytometric immunophenotyping revealed HCL. The oral lesion resolved after antiviral therapy. The intriguing possibility of a combined pathogenesis for the two disorders is considered, as HCL is known to be associated with immunosuppression, second malignancies and the production of cytokines promoting epithelial growth.

Entities:  

Keywords:  Immunosuppression; Oral premalignant lesions; Pseudoepitheliomatous hyperplasia

Year:  2016        PMID： 27656454      PMCID： PMC5028520          DOI： 10.7860/JCDR/2016/20751.8322

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN： 0973-709X


  13 in total

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4.  Comparative study of the expression of p53, Ki67, E-cadherin and MMP-1 in verrucous hyperplasia and verrucous carcinoma of the oral cavity.

Authors:  Hagen Benjamin Edward Klieb; Simon J Raphael
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5.  Treatment of hairy cell leukemia with cladribine (2-chlorodeoxyadenosine) by subcutaneous bolus injection: a phase II study.

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Review 7.  Autocrine and paracrine regulation of neoplastic cell growth in hairy cell leukemia.

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Journal:  Leuk Lymphoma       Date:  1995-05

8.  Second malignancies in patients with hairy cell leukemia in british columbia: a 20-year experience.

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Journal:  Blood       Date:  1998-08-15       Impact factor: 22.113

9.  2-chlorodeoxyadenosine induces durable remissions and prolonged suppression of CD4+ lymphocyte counts in patients with hairy cell leukemia.

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Journal:  Blood       Date:  1994-05-15       Impact factor: 22.113

10.  Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans.

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