Niranjan Gopal1, Reeta Rajagambeeram2, Shruthi Venkatkumar3, Mohana Valli Vijayan4, Sathish Babu Murugaiyan2, Shyam Prakash Gopal5, Sathiya Ramsamy4, Velayutharaj Alwar6. 1. Associate Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute , Pondicherry, India . 2. Assistant Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute , Pondicherry, India . 3. Student, Indira Gandhi Institute of Dental Sciences (IGIDS) , SBV (NAAC 'A' Grade), Pillaiyarkuppam, Pondicherry, India . 4. Tutor, Department of Biochemistry, Mahatma Gandhi Medical College & Research Institute , Pondicherry, India . 5. Student, M Pharm in Pharmacology, Mother Theresa Post Graduate and Research Institute of Health sciences , Indira Nagar, Gorimedu, Puducherry, India . 6. Assistant Professor, Department of Biochemistry, Chennai Medical College , Hospital & Research Centre, Trichy- Tamil Nadu, India .
Abstract
INTRODUCTION: The monitoring of glycaemic status in patients with T2DM is mainly through blood tests (Fasting plasma glucose and HbA1c), which are invasive and involves painful pricks. This leads to poor patient compliance and soon could lead to various micro and macro vascular complications, which hamper the quality of life. There are no sensitive and specific markers to predict these complications at the earliest. Sialochemistry has recently gained attention for monitoring chronic diseases. Osteopontin is a phospho-glycoprotein molecule, elevated in many inflammatory conditions. AIM: The aim of the study was to evaluate the role of serum and salivary osteopontin in Type 2 Diabetes mellitus (T2DM). MATERIALS AND METHODS: In this case-control study, we recruited 33 cases of T2DM and 31 age and gender matched healthy controls. Body Mass Index (BMI), Waist/Hip Ratio (WHR), Waist Circumference (WC) and blood pressure was recorded. Fasting Plasma Glucose (FPG), salivary glucose, HbA1c, microalbuminuria, systolic BP, serum and salivary osteopontin levels were estimated. RESULTS: FPG, salivary glucose, HbA1c, microalbuminuria, systolic BP, BMI, waist / hip ratio serum and salivary osteopontin levels were significantly high in T2DM cases compared to control subjects. Serum and salivary osteopontin levels were significantly correlated with HbA1c and microalbuminuria in T2DM cases. CONCLUSION: Serum and salivary osteopontin levels are significantly elevated in subjects with T2DM and are associated with glycaemic control and microalbuminuria.
INTRODUCTION: The monitoring of glycaemic status in patients with T2DM is mainly through blood tests (Fasting plasma glucose and HbA1c), which are invasive and involves painful pricks. This leads to poor patient compliance and soon could lead to various micro and macro vascular complications, which hamper the quality of life. There are no sensitive and specific markers to predict these complications at the earliest. Sialochemistry has recently gained attention for monitoring chronic diseases. Osteopontin is a phospho-glycoprotein molecule, elevated in many inflammatory conditions. AIM: The aim of the study was to evaluate the role of serum and salivary osteopontin in Type 2 Diabetes mellitus (T2DM). MATERIALS AND METHODS: In this case-control study, we recruited 33 cases of T2DM and 31 age and gender matched healthy controls. Body Mass Index (BMI), Waist/Hip Ratio (WHR), Waist Circumference (WC) and blood pressure was recorded. Fasting Plasma Glucose (FPG), salivary glucose, HbA1c, microalbuminuria, systolic BP, serum and salivary osteopontin levels were estimated. RESULTS: FPG, salivary glucose, HbA1c, microalbuminuria, systolic BP, BMI, waist / hip ratio serum and salivary osteopontin levels were significantly high in T2DM cases compared to control subjects. Serum and salivary osteopontin levels were significantly correlated with HbA1c and microalbuminuria in T2DM cases. CONCLUSION: Serum and salivary osteopontin levels are significantly elevated in subjects with T2DM and are associated with glycaemic control and microalbuminuria.
Authors: Vidya Kadashetti; Rajendra Baad; Neelima Malik; K M Shivakumar; Nupura Vibhute; Uzma Belgaumi; Sushma Gugawad; R C Pramod Journal: Rom J Intern Med Date: 2015 Jul-Sep