R A Brown1, G J Kemp2, S A Walkinshaw3, Mlp Howse1. 1. Royal Liverpool and Broadgreen University Hospitals NHS Trust, UK. 2. Institute of Ageing and Chronic Disease, University of Liverpool, UK. 3. Liverpool Women's NHS Foundation Trust, UK.
Abstract
OBJECTIVE: To examine the impact of nephrotic range proteinuria during pregnancy on renal, maternal and fetal outcomes. METHODS: A retrospective study of pregnant women with proteinuria greater than 3 g/24 h. Outcome measures included: gestation and mode of delivery, maternal high dependency unit admission, birth weight, maternal blood pressure and proteinuria at time of last follow-up, renal biopsy. RESULTS: Two hundred and sixty four pregnancies in 262 women were reviewed. Postnatal data were available in 180; of these 104 (57%) had urinary protein quantified postnatally. Sixty three (60%) were pure preeclampsia and nine (9%) super-imposed preeclampsia. Biopsy-proven renal disease was newly diagnosed in nine (9%). Sixty three per cent required caesarean section and 34% required high dependency unit admission. There were no maternal deaths. Birth weight corrected for gestation was below the fifth centile in 33%. CONCLUSIONS: The incidence of underlying renal pathology in this cohort is significant and highlights the importance of careful follow-up.
OBJECTIVE: To examine the impact of nephrotic range proteinuria during pregnancy on renal, maternal and fetal outcomes. METHODS: A retrospective study of pregnant women with proteinuria greater than 3 g/24 h. Outcome measures included: gestation and mode of delivery, maternal high dependency unit admission, birth weight, maternal blood pressure and proteinuria at time of last follow-up, renal biopsy. RESULTS: Two hundred and sixty four pregnancies in 262 women were reviewed. Postnatal data were available in 180; of these 104 (57%) had urinary protein quantified postnatally. Sixty three (60%) were pure preeclampsia and nine (9%) super-imposed preeclampsia. Biopsy-proven renal disease was newly diagnosed in nine (9%). Sixty three per cent required caesarean section and 34% required high dependency unit admission. There were no maternal deaths. Birth weight corrected for gestation was below the fifth centile in 33%. CONCLUSIONS: The incidence of underlying renal pathology in this cohort is significant and highlights the importance of careful follow-up.
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