Literature DB >> 27655914

The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.

Dongmei Zhang1,2, M Caleb Marlin2, Zhimin Liang2, Mohiuddin Ahmad3, Nicole M Ashpole4, William E Sonntag4, Zhizhuang Joe Zhao5,6, Guangpu Li7,6.   

Abstract

Protein tyrosine phosphatase MEG2 (PTP-MEG2) is a unique nonreceptor tyrosine phosphatase associated with transport vesicles, where it facilitates membrane trafficking by dephosphorylation of the N-ethylmaleimide-sensitive fusion factor. In this study, we identify the neurotrophin receptor TrkA as a novel cargo whose transport to the cell surface requires PTP-MEG2 activity. In addition, TrkA is also a novel substrate of PTP-MEG2, which dephosphorylates both Tyr-490 and Tyr-674/Tyr-675 of TrkA. As a result, overexpression of PTP-MEG2 down-regulates NGF/TrkA signaling and blocks neurite outgrowth and differentiation in PC12 cells and cortical neurons.
© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  PTP-MEG2; PTPN9; TrkA; autophosphorylation; membrane trafficking; neuron; receptor tyrosine kinase; tyrosine-protein phosphatase (tyrosine phosphatase)

Mesh：

Substances：

Year:  2016        PMID： 27655914      PMCID： PMC5104914          DOI： 10.1074/jbc.M116.728550

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  17 in total

1.  Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides.

Authors:  Joshua M Kruger; Takayasu Fukushima; Vera Cherepanov; Niels Borregaard; Carola Loeve; Christina Shek; Kalpana Sharma; A Keith Tanswell; Chung-Wai Chow; Gregory P Downey
Journal:  J Biol Chem       Date:  2001-11-15       Impact factor: 5.157

2.  Enlargement of secretory vesicles by protein tyrosine phosphatase PTP-MEG2 in rat basophilic leukemia mast cells and Jurkat T cells.

Authors:  Xiaodong Wang; Huong Huynh; Anette Gjörloff-Wingren; Edvard Monosov; Mats Stridsberg; Minoru Fukuda; Tomas Mustelin
Journal:  J Immunol       Date:  2002-05-01       Impact factor: 5.422

Review 3.  Trk receptors: roles in neuronal signal transduction.

Authors:  Eric J Huang; Louis F Reichardt
Journal:  Annu Rev Biochem       Date:  2003-03-27       Impact factor: 23.643

4.  Specific interaction of protein tyrosine phosphatase-MEG2 with phosphatidylserine.

Authors:  Runxiang Zhao; Xueqi Fu; Qingshan Li; Sanford B Krantz; Zhizhuang Joe Zhao
Journal:  J Biol Chem       Date:  2003-04-17       Impact factor: 5.157

5.  Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins.

Authors:  Kan Saito; Scott Williams; Anna Bulankina; Stefan Höning; Tomas Mustelin
Journal:  J Biol Chem       Date:  2007-03-26       Impact factor: 5.157

6.  Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor.

Authors:  J Zhou; J S Valletta; M L Grimes; W C Mobley
Journal:  J Neurochem       Date:  1995-09       Impact factor: 5.372

7.  Control of vesicle fusion by a tyrosine phosphatase.

Authors:  Huong Huynh; Nunzio Bottini; Scott Williams; Vera Cherepanov; Lucia Musumeci; Kan Saito; Shane Bruckner; Eric Vachon; Xiaodong Wang; Joshua Kruger; Chung-Wai Chow; Maurizio Pellecchia; Edvard Monosov; Peter A Greer; William Trimble; Gregory P Downey; Tomas Mustelin
Journal:  Nat Cell Biol       Date:  2004-08-22       Impact factor: 28.824

8.  Molecular kinetics of nerve growth factor receptor trafficking and activation.

Authors:  Jérôme Jullien; Vincent Guili; Louis F Reichardt; Brian B Rudkin
Journal:  J Biol Chem       Date:  2002-06-07       Impact factor: 5.157

9.  PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells.

Authors:  Ming-Jiang Xu; Xingwei Sui; Runxiang Zhao; Chunhua Dai; Sanford B Krantz; Zhizhuang Joe Zhao
Journal:  Blood       Date:  2003-08-14       Impact factor: 22.113

10.  Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function.

Authors:  Yingchun Wang; Eric Vachon; Jinyi Zhang; Vera Cherepanov; Joshua Kruger; Jun Li; Kan Saito; Patrick Shannon; Nunzio Bottini; Huong Huynh; Heyu Ni; Hong Yang; Colin McKerlie; Sue Quaggin; Zhizhuang Joe Zhao; Philip A Marsden; Tomas Mustelin; Katherine A Siminovitch; Gregory P Downey
Journal:  J Exp Med       Date:  2005-12-05       Impact factor: 14.307
View more
  12 in total

1.  Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors.

Authors:  Naoya Yamashita; Rajshri Joshi; Sheng Zhang; Zhong-Yin Zhang; Rejji Kuruvilla
Journal:  Dev Cell       Date:  2017-09-14       Impact factor: 12.270

2.  The Non-Receptor Protein Tyrosine Phosphatase PTPN6 Mediates a Positive Regulatory Approach From the Interferon Regulatory Factor to the JAK/STAT Pathway in Litopenaeus vannamei.

Authors:  Mengting Luo; Xiaopeng Xu; Xinxin Liu; Wenjie Shen; Linwei Yang; Zhiming Zhu; Shaoping Weng; Jianguo He; Hongliang Zuo
Journal:  Front Immunol       Date:  2022-06-29       Impact factor: 8.786

3.  PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.

Authors:  Yun-Fei Xu; Xu Chen; Zhao Yang; Peng Xiao; Chun-Hua Liu; Kang-Shuai Li; Xiao-Zhen Yang; Yi-Jing Wang; Zhong-Liang Zhu; Zhi-Gang Xu; Sheng Zhang; Chuan Wang; You-Chen Song; Wei-Dong Zhao; Chang-He Wang; Zhi-Liang Ji; Zhong-Yin Zhang; Min Cui; Jin-Peng Sun; Xiao Yu
Journal:  EMBO Rep       Date:  2021-03-25       Impact factor: 8.807

4.  PTPN9 promotes cell proliferation and invasion in Eca109 cells and is negatively regulated by microRNA-126.

Authors:  Junwei Zhu; Haomiao Li; Jun Ma; Haibo Huang; Jianjun Qin; Yin Li
Journal:  Oncol Lett       Date:  2017-06-06       Impact factor: 2.967

5.  NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish.

Authors:  Chi-Hwa Yang; Yu-Jung Yeh; Jiz-Yuh Wang; Ya-Wen Liu; Yen-Lin Chen; Hui-Wen Cheng; Chun-Mei Cheng; Yung-Jen Chuang; Chiou-Hwa Yuh; Yi-Rong Chen
Journal:  Sci Rep       Date:  2017-07-12       Impact factor: 4.379

6.  Synthesis, bioactivity, 3D-QSAR studies of novel dibenzofuran derivatives as PTP-MEG2 inhibitors.

Authors:  Ying Ma; Hui-Yu Wei; Yu-Ze Zhang; Wen-Yan Jin; Hong-Lian Li; Hui Zhou; Xian-Chao Cheng; Run-Ling Wang
Journal:  Oncotarget       Date:  2017-06-13

7.  NOX2-Dependent Reactive Oxygen Species Regulate Formyl-Peptide Receptor 1-Mediated TrkA Transactivation in SH-SY5Y Cells.

Authors:  Martina Castaldo; Cristiana Zollo; Gabriella Esposito; Rosario Ammendola; Fabio Cattaneo
Journal:  Oxid Med Cell Longev       Date:  2019-12-02       Impact factor: 6.543

Review 8.  The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma.

Authors:  Yide Huang; Yafei Zhang; Lilin Ge; Yao Lin; Hang Fai Kwok
Journal:  Cancers (Basel)       Date:  2018-03-20       Impact factor: 6.639

Review 9.  Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling.

Authors:  Mihwa Kim; Liza D Morales; Ik-Soon Jang; Yong-Yeon Cho; Dae Joon Kim
Journal:  Int J Mol Sci       Date:  2018-09-11       Impact factor: 5.923

10.  PTPN9 induces cell apoptosis by mitigating the activation of Stat3 and acts as a tumor suppressor in colorectal cancer.

Authors:  Dawei Wang; Zhuoxin Cheng; Ming Zhao; Chengbin Jiao; Qinghui Meng; Huayang Pan; Yu Xie; Long Li; Yexing Zhu; Wei Wang; Chunlei Qu; Deshen Liang
Journal:  Cancer Manag Res       Date:  2019-02-08       Impact factor: 3.989
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.