Nicole D Ford1, Reynaldo Martorell1,2, Neil K Mehta2, Manuel Ramirez-Zea3, Aryeh D Stein4,2. 1. Nutrition and Health Sciences Program, Laney Graduate School, and. 2. Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA; and. 3. Institute of Nutrition of Central America and Panama Research Center for the Prevention of Chronic Diseases (CIIPEC), Guatemala City, Guatemala. 4. Nutrition and Health Sciences Program, Laney Graduate School, and aryeh.stein@emory.edu.
Abstract
BACKGROUND: Latin America has experienced increases in obesity. Little is known about the role of early life factors on body mass index (BMI) gain over the life course. OBJECTIVE: The objective of this research was to examine the role of early life factors [specifically, nutrition supplementation during the first 1000 d (from conception to 2 y of age) and childhood household socioeconomic status (SES)] on the pattern of BMI gain from birth or early childhood through midadulthood by using latent class growth analysis. METHODS:Study participants (711 women, 742 men) who were born in 4 villages in Guatemala (1962-1977) were followed prospectively since participating in a randomized nutrition supplementation trial as children. Sex-specific BMI latent class trajectories were derived from 22 possible measures of height and weight from 1969 to 2004. To characterize early life determinants of BMI latent class membership, we used logistic regression modeling and estimated the difference-in-difference (DD) effect of nutrition supplementation during the first 1000 d. RESULTS: We identified 2 BMI latent classesin women [low (57%) and high (43%)] and 3 classes in men [low (38%), medium (47%), and high (15%)]. Nutrition supplementation during the first 1000 d after conception was not associated with BMI latent class membership (DD test: P > 0.15 for men and women), whereas higher SES was associated with increased odds of high BMI latent class membership in both men (OR: 1.98; 95% CI: 1.09, 3.61) and women (OR: 1.62; 95% CI: 1.07, 2.45) for the highest relative to the lowest tertile. CONCLUSIONS: In a cohort of Guatemalan men and women, nutrition supplementation provided during the first 1000 d was not significantly associated with higher BMI trajectory. Higher childhood household SES was associated with increased odds of high BMI latent class membership relative to the poorest households. The pathways through which this operates still need to be explored.
RCT Entities:
BACKGROUND: Latin America has experienced increases in obesity. Little is known about the role of early life factors on body mass index (BMI) gain over the life course. OBJECTIVE: The objective of this research was to examine the role of early life factors [specifically, nutrition supplementation during the first 1000 d (from conception to 2 y of age) and childhood household socioeconomic status (SES)] on the pattern of BMI gain from birth or early childhood through midadulthood by using latent class growth analysis. METHODS: Study participants (711 women, 742 men) who were born in 4 villages in Guatemala (1962-1977) were followed prospectively since participating in a randomized nutrition supplementation trial as children. Sex-specific BMI latent class trajectories were derived from 22 possible measures of height and weight from 1969 to 2004. To characterize early life determinants of BMI latent class membership, we used logistic regression modeling and estimated the difference-in-difference (DD) effect of nutrition supplementation during the first 1000 d. RESULTS: We identified 2 BMI latent classes in women [low (57%) and high (43%)] and 3 classes in men [low (38%), medium (47%), and high (15%)]. Nutrition supplementation during the first 1000 d after conception was not associated with BMI latent class membership (DD test: P > 0.15 for men and women), whereas higher SES was associated with increased odds of high BMI latent class membership in both men (OR: 1.98; 95% CI: 1.09, 3.61) and women (OR: 1.62; 95% CI: 1.07, 2.45) for the highest relative to the lowest tertile. CONCLUSIONS: In a cohort of Guatemalan men and women, nutrition supplementation provided during the first 1000 d was not significantly associated with higher BMI trajectory. Higher childhood household SES was associated with increased odds of high BMI latent class membership relative to the poorest households. The pathways through which this operates still need to be explored.
Authors: Rubén Grajeda; Jere R Behrman; Rafael Flores; John A Maluccio; Reynaldo Martorell; Aryeh D Stein Journal: Food Nutr Bull Date: 2005-06 Impact factor: 2.069
Authors: Verity Cleland; Jing Tian; Marie-Jeanne Buscot; Costan G Magnussen; Lydia Bazzano; Trudy L Burns; Stephen Daniels; Terence Dwyer; Nina Hutri-Kahonen; Johanna Ikonen; David Jacobs; Markus Juonala; Ronald Prineas; Olli Raitakari; Alan Sinaiko; Julia Steinberger; Elaine M Urbina; Jessica G Woo; Alison Venn Journal: EClinicalMedicine Date: 2022-05-12
Authors: Ines Gonzalez Casanova; Ann DiGirolamo; Maria F Kroker-Lobos; Laura Ochaeta; Manuel Ramirez-Zea; Reynaldo Martorell; Aryeh D Stein Journal: BMJ Open Date: 2021-06-30 Impact factor: 2.692
Authors: Nicole D Ford; Reynaldo Martorell; Neil K Mehta; Cria G Perrine; Manuel Ramirez-Zea; Aryeh D Stein Journal: PLoS One Date: 2020-10-22 Impact factor: 3.240