OBJECTIVE: To study the possible immunological mechanism of wheezing attack in children with cytomegalovirus (CMV) infection. METHODS: A total of 25 under-5-year-old children with wheezing following CMV infection were enrolled. The expression of serum regulatory T cells (Treg)/T helper 17 (Th17) cytokines interleukin (IL)-10, IL-6, and IL-17, and peripheral blood lymphocyte subsets were determined. Twenty age-matched healthy children were selected as the control group. RESULTS: The wheezing group had a significantly reduced serum IL-10 level, significantly increased IL-6 and IL-17 levels, significantly reduced levels of natural killer cells, and significantly increased levels of CD8+ T cells and CD19+ B cells, as compared with the control group. CONCLUSIONS: Wheezing children with CMV infection have Treg/Th17 imbalance and cellular immune dysfunction, which may be an important immunological mechanism of the development of wheezing in children after CMV infection.
OBJECTIVE: To study the possible immunological mechanism of wheezing attack in children with cytomegalovirus (CMV) infection. METHODS: A total of 25 under-5-year-old children with wheezing following CMV infection were enrolled. The expression of serum regulatory T cells (Treg)/T helper 17 (Th17) cytokines interleukin (IL)-10, IL-6, and IL-17, and peripheral blood lymphocyte subsets were determined. Twenty age-matched healthy children were selected as the control group. RESULTS: The wheezing group had a significantly reduced serum IL-10 level, significantly increased IL-6 and IL-17 levels, significantly reduced levels of natural killer cells, and significantly increased levels of CD8+ T cells and CD19+ B cells, as compared with the control group. CONCLUSIONS:Wheezingchildren with CMV infection have Treg/Th17 imbalance and cellular immune dysfunction, which may be an important immunological mechanism of the development of wheezing in children after CMV infection.
Authors: Luka Cicin-Sain; Andrew W Sylwester; Shoko I Hagen; Don C Siess; Noreen Currier; Alfred W Legasse; Miranda B Fischer; Caroline W Koudelka; Michael K Axthelm; Janko Nikolich-Zugich; Louis J Picker Journal: J Immunol Date: 2011-07-15 Impact factor: 5.422
Authors: Tuomas Jartti; Maria Paul-Anttila; Pasi Lehtinen; Vilhelmiina Parikka; Tytti Vuorinen; Olli Simell; Olli Ruuskanen Journal: Respir Res Date: 2009-09-25
Authors: Rafael Solana; Raquel Tarazona; Allison E Aiello; Arne N Akbar; Victor Appay; Mark Beswick; Jos A Bosch; Carmen Campos; Sara Cantisán; Luka Cicin-Sain; Evelyna Derhovanessian; Sara Ferrando-Martínez; Daniela Frasca; Tamas Fulöp; Sheila Govind; Beatrix Grubeck-Loebenstein; Ann Hill; Mikko Hurme; Florian Kern; Anis Larbi; Miguel López-Botet; Andrea B Maier; Janet E McElhaney; Paul Moss; Elissaveta Naumova; Janko Nikolich-Zugich; Alejandra Pera; Jerrald L Rector; Natalie Riddell; Beatriz Sanchez-Correa; Paolo Sansoni; Delphine Sauce; Rene van Lier; George C Wang; Mark R Wills; Maciej Zieliński; Graham Pawelec Journal: Immun Ageing Date: 2012-10-31 Impact factor: 6.400