| Literature DB >> 27655286 |
Zhao Xiaohong1, Fan Lichun1, Xie Na2, Zou Kejian3, Xiao Xiaolan4, Wang Shaosheng5.
Abstract
MicroRNAs (miRNAs) play an important role in the tumorigenesis of ovarian cancer. Previously, we have reported the dysregulation of miR-203 in the ovarian cancer tissues. However, the biological functions and molecular mechanisms of miR-203 in ovarian cancer remain unknown. Here, we showed that the expression of miR-203 was increased in ovarian cancer tissues compared with the adjacent non-cancerous tissues and the transcription of miR-203 was inhibited by P53. Forced expression of miR-203 in ovarian cancer promoted cell growth and migration, while depletion of miR-203 inhibited the growth and migration of ovarian cancer cells. In addition, miR-203 promoted the metastasis of ovarian cancer cells in vivo and shorted the survival of the nude mice. Mechanically, miR-203 targeted the 3'-UTR of pyruvate dehydrogenase B (PDHB) and increased the consumption of glucose and the production of lactate. Overexpression of PDHB abolished the oncogenic effects of miR-203 on the growth of ovarian cancer cells. Together, our data suggested the oncogenic roles of miR-203 in ovarian cancer by promoting glycolysis, and miR-203 might be a therapeutic target for ovarian cancer.Entities:
Keywords: Cell growth and migration; Glycolysis; MiR-203; Ovarian cancer; PDHB
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Year: 2016 PMID： 27655286 DOI： 10.1007/s13277-016-5415-1
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283