Yoo Seung Chung1, Joon-Hyop Lee1, Young Don Lee2. 1. Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Gachon University, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Republic of Korea. 2. Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Gachon University, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Republic of Korea. peacemk@gilhospital.com.
Abstract
PURPOSE: Obesity appears to be related to papillary thyroid carcinoma (PTC) in the observational studies, although its relationship concerning the PTC prognosis has not been established. We investigated the association between body mass index (BMI) and the prognosis of PTC. METHODS: The WHO BMI classification was used to stratify the degree of obesity. The final outcome was disease status, including recurrence and persistence, of 783 PTC patients. We reviewed patients' BMI, disease status, and other prognostic factors retrospectively. RESULTS: The mean BMI was 24.2 kg/m2. When stratified according to the WHO BMI classification, 21 were Underweight, 482 were Normal, 232 were Overweight, and 48 were Obese. We divided patients into two groups: <25.0 kg/m2 (n = 503) vs. ≥25.0 kg/m2 (n = 280). The BMI ≥25.0 group was older and more likely to be male in a multivariate analysis (p < 0.001). For those with BMI <25.0 and ≥25.0, recurrence occurred in 3.0 and 2.1 % (p = 0.486), persistence in 7.2 and 5.1 % (p = 0.265), and either recurrence or persistence in 9.9 and 7.1 %, respectively (p = 0.189). A multivariate analysis revealed that older age and male gender in Overweight vs. Normal, older age in Obese vs. Normal, and advanced T stage in Normal vs. Underweight were statistically significant prognostic factors. CONCLUSIONS: There was no significant difference in the prognosis according to BMI in PTC patients. However, old age, male gender, and advanced T-stage patients were found more frequently in the higher BMI group than in the lower BMI group.
PURPOSE:Obesity appears to be related to papillary thyroid carcinoma (PTC) in the observational studies, although its relationship concerning the PTC prognosis has not been established. We investigated the association between body mass index (BMI) and the prognosis of PTC. METHODS: The WHO BMI classification was used to stratify the degree of obesity. The final outcome was disease status, including recurrence and persistence, of 783 PTCpatients. We reviewed patients' BMI, disease status, and other prognostic factors retrospectively. RESULTS: The mean BMI was 24.2 kg/m2. When stratified according to the WHO BMI classification, 21 were Underweight, 482 were Normal, 232 were Overweight, and 48 were Obese. We divided patients into two groups: <25.0 kg/m2 (n = 503) vs. ≥25.0 kg/m2 (n = 280). The BMI ≥25.0 group was older and more likely to be male in a multivariate analysis (p < 0.001). For those with BMI <25.0 and ≥25.0, recurrence occurred in 3.0 and 2.1 % (p = 0.486), persistence in 7.2 and 5.1 % (p = 0.265), and either recurrence or persistence in 9.9 and 7.1 %, respectively (p = 0.189). A multivariate analysis revealed that older age and male gender in Overweight vs. Normal, older age in Obese vs. Normal, and advanced T stage in Normal vs. Underweight were statistically significant prognostic factors. CONCLUSIONS: There was no significant difference in the prognosis according to BMI in PTCpatients. However, old age, male gender, and advanced T-stage patients were found more frequently in the higher BMI group than in the lower BMI group.
Authors: John E Paes; Keding Hua; Rebecca Nagy; Richard T Kloos; David Jarjoura; Matthew D Ringel Journal: J Clin Endocrinol Metab Date: 2010-06-02 Impact factor: 5.958
Authors: Li Xu; Matthias Port; Stefano Landi; Federica Gemignani; Monica Cipollini; Rossella Elisei; Lilia Goudeva; Jörg Andreas Müller; Kai Nerlich; Giovanni Pellegrini; Christoph Reiners; Cristina Romei; Robert Schwab; Michael Abend; Erich M Sturgis Journal: Thyroid Date: 2014-05-05 Impact factor: 6.568
Authors: Danuta Gąsior-Perczak; Iwona Pałyga; Monika Szymonek; Artur Kowalik; Agnieszka Walczyk; Janusz Kopczyński; Katarzyna Lizis-Kolus; Tomasz Trybek; Estera Mikina; Dorota Szyska-Skrobot; Klaudia Gadawska-Juszczyk; Stefan Hurej; Artur Szczodry; Anna Słuszniak; Janusz Słuszniak; Ryszard Mężyk; Stanisław Góźdź; Aldona Kowalska Journal: PLoS One Date: 2018-10-01 Impact factor: 3.240