Seung Hyen Lee1, Da-Ae Yu2, Tae-Woo Kim1, Eun Ji Lee1, Michaël J A Girard3, Jean Martial Mari4. 1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. 2. Seoul National University College of Medicine, Seoul, Korea. 3. Department of Biomedical Engineering, National University of Singapore, Singapore 4Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. 4. GePaSud, Université de la Polynésie Française, Tahiti, French Polynesia.
Abstract
PURPOSE: To investigate whether the lamina cribrosa (LC) curvature is decreased after trabeculectomy. METHODS: Thirty-nine eyes of 39 patients with primary open-angle glaucoma who underwent trabeculectomy were included. Optic nerves were scanned by using enhanced-depth-imaging spectral-domain optical coherence tomography before and after trabeculectomy. The LC curvature was assessed by measuring the LC curvature index (LCCI) in seven horizontal B-scan images in each eye. RESULTS: The LCCI was significantly smaller at postoperative 6 months than at the preoperative level in all seven planes (all P < 0.001). Preoperative LCCI was associated with younger age at superior midperiphery, midhorizontal plane, inferior midperiphery (all P ≤ 0.005) and higher preoperative intraocular pressure (IOP) at superior and inferior midperiphery (both P = 0.039). Younger age and larger preoperative LCCI were associated with a larger reduction of the LCCI at all three locations (P = 0.003 and 0.031 at superior midperiphery, P = 0.011 and 0.001 at midhorizontal plane, and P = 0.014 and 0.005 at inferior midperiphery, respectively), whereas the percentage IOP lowering was associated at superior and inferior midperiphery (P = 0.017 and 0.047, respectively). CONCLUSIONS: Lamina cribrosa curvature was reduced after trabeculectomy. This finding suggests that LC curvature may have value as a parameter relevant to optic nerve head biomechanics.
PURPOSE: To investigate whether the lamina cribrosa (LC) curvature is decreased after trabeculectomy. METHODS: Thirty-nine eyes of 39 patients with primary open-angle glaucoma who underwent trabeculectomy were included. Optic nerves were scanned by using enhanced-depth-imaging spectral-domain optical coherence tomography before and after trabeculectomy. The LC curvature was assessed by measuring the LC curvature index (LCCI) in seven horizontal B-scan images in each eye. RESULTS: The LCCI was significantly smaller at postoperative 6 months than at the preoperative level in all seven planes (all P < 0.001). Preoperative LCCI was associated with younger age at superior midperiphery, midhorizontal plane, inferior midperiphery (all P ≤ 0.005) and higher preoperative intraocular pressure (IOP) at superior and inferior midperiphery (both P = 0.039). Younger age and larger preoperative LCCI were associated with a larger reduction of the LCCI at all three locations (P = 0.003 and 0.031 at superior midperiphery, P = 0.011 and 0.001 at midhorizontal plane, and P = 0.014 and 0.005 at inferior midperiphery, respectively), whereas the percentage IOP lowering was associated at superior and inferior midperiphery (P = 0.017 and 0.047, respectively). CONCLUSIONS: Lamina cribrosa curvature was reduced after trabeculectomy. This finding suggests that LC curvature may have value as a parameter relevant to optic nerve head biomechanics.
Authors: Jeong-Ah Kim; Tae-Woo Kim; Robert N Weinreb; Eun Ji Lee; Michaël J A Girard; Jean Martial Mari Journal: Sci Rep Date: 2018-01-15 Impact factor: 4.379
Authors: Seung Hyen Lee; Eun Ji Lee; Joon Mo Kim; Michaël J A Girard; Jean Martial Mari; Tae-Woo Kim Journal: Invest Ophthalmol Vis Sci Date: 2020-06-03 Impact factor: 4.799