C Sanfilippo1, L Malaguarnera2, M Di Rosa3. 1. Section of Neurosciences, Department G.F. Ingrassia, University of Catania, Via Santa Sofia, 78, 95123 Catania, Italy. 2. Department of Biomedical and Biotechnological Sciences, University of Catania, Italy. 3. Department of Biomedical and Biotechnological Sciences, University of Catania, Italy. Electronic address: mdirosa@unict.it.
Abstract
BACKGROUND: Alzheimer disease is the most typical form of dementia. The causes of AD are not yet completely understood, but they include a combination of genetic, environmental and lifestyle factors that influence ja person's risk for developing the disease. New biomarkers related to these processes could be important for the diagnosis and follow-up of AD patients. OBJECTIVE: The intent of this study was to weigh the expression levels of chitinases genes in brain regions of late-onset AD (LOAD) patients. MATERIALS AND METHODS: We analysed three microarray datasets obtained from the NCBI in order to verify the expression levels of chitinase genes family in brain biopsies (CR, DLPFC and VC) of LOAD patients compared to healthy subjects. We also divided the sample in function of sex difference and ages. RESULTS: The analysis showed that all chitinases genes were modulated in LOAD brain regions compared to healthy subjects. Furthermore positively correlation was identified between chitinases gene expression and healthy age's subjects. Moreover, it has been shown that CHI3L1 and CHI3L2 were regulated differently in healthy and LOAD brain depending on the sex. CONCLUSION: It is possible to conclude that all chitinases could be considered new potential markers for LOAD disease.
BACKGROUND:Alzheimer disease is the most typical form of dementia. The causes of AD are not yet completely understood, but they include a combination of genetic, environmental and lifestyle factors that influence ja person's risk for developing the disease. New biomarkers related to these processes could be important for the diagnosis and follow-up of ADpatients. OBJECTIVE: The intent of this study was to weigh the expression levels of chitinases genes in brain regions of late-onset AD (LOAD) patients. MATERIALS AND METHODS: We analysed three microarray datasets obtained from the NCBI in order to verify the expression levels of chitinase genes family in brain biopsies (CR, DLPFC and VC) of LOAD patients compared to healthy subjects. We also divided the sample in function of sex difference and ages. RESULTS: The analysis showed that all chitinases genes were modulated in LOAD brain regions compared to healthy subjects. Furthermore positively correlation was identified between chitinases gene expression and healthy age's subjects. Moreover, it has been shown that CHI3L1 and CHI3L2 were regulated differently in healthy and LOAD brain depending on the sex. CONCLUSION: It is possible to conclude that all chitinases could be considered new potential markers for LOAD disease.
Authors: Cristina Sanfilippo; Paola Castrogiovanni; Manlio Vinciguerra; Rosa Imbesi; Martina Ulivieri; Francesco Fazio; Kaj Blennow; Henrik Zetterberg; Michelino Di Rosa Journal: Geroscience Date: 2022-09-22 Impact factor: 7.581
Authors: Kevin Connolly; Mikael Lehoux; Ryan O'Rourke; Benedetta Assetta; Guzide Ayse Erdemir; Jack A Elias; Chun Geun Lee; Yu-Wen Alvin Huang Journal: Alzheimers Dement Date: 2022-03-02 Impact factor: 16.655
Authors: Cristina Sanfilippo; Giuseppe Musumeci; Maria Kazakova; Venera Mazzone; Paola Castrogiovanni; Rosa Imbesi; Michelino Di Rosa Journal: J Mol Neurosci Date: 2020-10-15 Impact factor: 3.444
Authors: Paola Catrogiovanni; Giuseppe Musumeci; Salvatore Giunta; Rosa Imbesi; Michelino Di Rosa Journal: Inflamm Res Date: 2020-06-04 Impact factor: 6.986