László Horváth1, Klára Fekete2, Sándor Márton3, István Fekete4. 1. University of Debrecen, Faculty of Pharmacy, Department of Pharmaceutical Surveillance and Economy, Nagyerdei krt. 98., Debrecen, Hungary. Electronic address: lhorvath@med.unideb.hu. 2. University of Debrecen, Faculty of Medicine, Department of Neurology, Móricz Zs. krt. 22., Debrecen, Hungary. Electronic address: feketek@med.unideb.hu. 3. University of Debrecen, Faculty of Art, Institute of Political Science and Sociology, Egyetem tér 1., Debrecen, Hungary. Electronic address: marton.sandor@arts.unideb.hu. 4. University of Debrecen, Faculty of Medicine, Department of Neurology, Móricz Zs. krt. 22., Debrecen, Hungary. Electronic address: fekete@med.unideb.hu.
Abstract
OBJECTIVE: The aim of this study was to determine the outcome of antiepileptic drug (AED) treatment based on seizure freedom, pharmacovigilance reports and effects of concomitant medication on the central nervous system (CNS) of adult epileptic patients registered in the East-Hungarian Epilepsy Database. METHODS: Prospective cross-sectional database was compiled from outpatient files between 1992 and 2011. RESULTS: The majority of 1282 treated patients were on monotherapy 894 patients (70%), 286 (22%) on bitherapy and 102 (8%) on polytherapy. Of all treated patients, seizure freedom was achieved by 603 (47%). Among the seizure free patients 464 (77%) were on monotherapy, 115 (19%) on bitherapy and only 24 (4%) on polytherapy. The overall rate of adverse drug reactions (ADRs) was 16.2%. From patients on AED, 279 (22%) took concomitant drugs acting on the CNS. In a logistic regression model, other CNS-related drugs and a number of prescribed antiepileptic drugs had a significant influence on the desired outcome of seizure freedom. On comparing the Proportional Reporting Ratio and 95%CI of older and newer AEDs, no significant superiority of newer AEDs was detected. CONCLUSION: Careful drug selection for epileptic patients must be highlighted in order to improve outcome, reduce ADRs and improve patient compliance.
OBJECTIVE: The aim of this study was to determine the outcome of antiepileptic drug (AED) treatment based on seizure freedom, pharmacovigilance reports and effects of concomitant medication on the central nervous system (CNS) of adult epilepticpatients registered in the East-Hungarian Epilepsy Database. METHODS: Prospective cross-sectional database was compiled from outpatient files between 1992 and 2011. RESULTS: The majority of 1282 treated patients were on monotherapy 894 patients (70%), 286 (22%) on bitherapy and 102 (8%) on polytherapy. Of all treated patients, seizure freedom was achieved by 603 (47%). Among the seizure free patients 464 (77%) were on monotherapy, 115 (19%) on bitherapy and only 24 (4%) on polytherapy. The overall rate of adverse drug reactions (ADRs) was 16.2%. From patients on AED, 279 (22%) took concomitant drugs acting on the CNS. In a logistic regression model, other CNS-related drugs and a number of prescribed antiepileptic drugs had a significant influence on the desired outcome of seizure freedom. On comparing the Proportional Reporting Ratio and 95%CI of older and newer AEDs, no significant superiority of newer AEDs was detected. CONCLUSION: Careful drug selection for epilepticpatients must be highlighted in order to improve outcome, reduce ADRs and improve patient compliance.