Hyo Shin Kang1, Jung Hye Kwon2, Sangha Kim3, Duk L Na4, Seong Yoon Kim5, Jae-Hong Lee6, Seol-Heui Han7, Seong Hye Choi8, SangYun Kim9, Bernard J Carroll10, Doh Kwan Kim11. 1. Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Republic of Korea; Department of Clinical and Counseling Psychology, Korea University, Seoul, Republic of Korea. 2. Department of Clinical and Counseling Psychology, Korea University, Seoul, Republic of Korea. 3. Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea. 4. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 5. Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 6. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 7. Department of Neurology, Konkuk University School of Medicine, Seoul, Republic of Korea. 8. Department of Neurology, Inha University School of Medicine, Incheon, Republic of Korea. 9. Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea. 10. Pacific Behavioral Research Foundation, Carmel, CA, USA. 11. Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Republic of Korea; Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: paulkim@skku.edu.
Abstract
OBJECTS: We designed this study to extensively compare the neuropsychological profiles of Alzheimer's disease (AD) and mixed dementia (MD) in a large multicenter cohort of patients. Specifically, we performed subgroup analyses to examine group differences associated with dementia severity. METHODS: A total of 1021 AD patients and 577 MD patients were included from the Clinical Research Center for Dementia of South Korea (CREDOS) Study. All patients underwent comprehensive neuropsychological and functional ratings, as well as complete physical and neurological examinations. To avoid floor confounds, only patients with Clinical Dementia Rating (CDR) scores of 0.5-2.0 were included. RESULTS: Overall, MD patients showed worse performance in frontal/executive function than those with AD. Stratification by dementia severity revealed a significant difference in global cognitive function scores between AD and MD patients only in the low severity groups (CDR 0.5). Also, MD patients showed worse performance in frontal/executive function domains in the CDR 0.5 groups whereas they had better performance in the memory domain in the CDR 1 groups than did AD patients. Additionally, AD patients showed better performance than MD patients with respect to activities of daily living at CDR levels 0.5 and 1. All differences had disappeared at the CDR 2 level of global dementia severity. CONCLUSION: This study suggests that there are significant differences in neuropsychological profiles between AD and MD patients, with the pattern of this difference varying distinctively according to dementia severity.
OBJECTS: We designed this study to extensively compare the neuropsychological profiles of Alzheimer's disease (AD) and mixed dementia (MD) in a large multicenter cohort of patients. Specifically, we performed subgroup analyses to examine group differences associated with dementia severity. METHODS: A total of 1021 ADpatients and 577 MD patients were included from the Clinical Research Center for Dementia of South Korea (CREDOS) Study. All patients underwent comprehensive neuropsychological and functional ratings, as well as complete physical and neurological examinations. To avoid floor confounds, only patients with Clinical Dementia Rating (CDR) scores of 0.5-2.0 were included. RESULTS: Overall, MD patients showed worse performance in frontal/executive function than those with AD. Stratification by dementia severity revealed a significant difference in global cognitive function scores between AD and MD patients only in the low severity groups (CDR 0.5). Also, MD patients showed worse performance in frontal/executive function domains in the CDR 0.5 groups whereas they had better performance in the memory domain in the CDR 1 groups than did ADpatients. Additionally, ADpatients showed better performance than MD patients with respect to activities of daily living at CDR levels 0.5 and 1. All differences had disappeared at the CDR 2 level of global dementia severity. CONCLUSION: This study suggests that there are significant differences in neuropsychological profiles between AD and MD patients, with the pattern of this difference varying distinctively according to dementia severity.
Authors: Min Ju Kang; Sang Yun Kim; Duk L Na; Byeong C Kim; Dong Won Yang; Eun-Joo Kim; Hae Ri Na; Hyun Jeong Han; Jae-Hong Lee; Jong Hun Kim; Kee Hyung Park; Kyung Won Park; Seol-Heui Han; Seong Yoon Kim; Soo Jin Yoon; Bora Yoon; Sang Won Seo; So Young Moon; YoungSoon Yang; Yong S Shim; Min Jae Baek; Jee Hyang Jeong; Seong Hye Choi; Young Chul Youn Journal: BMC Med Inform Decis Mak Date: 2019-11-21 Impact factor: 2.796