Jack E Fisher1, Steffen Loft2, Charlotte S Ulrik3, Ole Raaschou-Nielsen4, Ole Hertel5, Anne Tjønneland4, Kim Overvad6,7, Mark J Nieuwenhuijsen8,9,10, Zorana J Andersen1. 1. 1 Center for Epidemiology and. 2. 2 Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 3. 3 Department of Respiratory Medicine, Hvidovre Hospital and University of Copenhagen, Hvidovre, Denmark. 4. 4 Danish Cancer Research Center, Danish Cancer Society, Copenhagen, Denmark. 5. 5 Department of Environmental Science, Aarhus University, Roskilde, Denmark. 6. 6 Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark. 7. 7 Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark. 8. 8 Center for Research in Environmental Epidemiology, Barcelona, Spain. 9. 9 Universitat Pompeu Fabra, Barcelona, Spain; and. 10. 10 Centro de Investigacion Biomedica en Red Epidemiología y Salud Pública, Barcelona, Spain.
Abstract
RATIONALE: Physical activity enhances uptake of air pollutants in the lung, possibly augmenting their harmful effects on chronic lung disease during exercise. OBJECTIVES: To examine whether benefits of physical activity with respect to the risk of asthma and chronic obstructive pulmonary disease (COPD) are moderated by exposure to high air pollution levels in an urban setting. METHODS: A total of 53,113 subjects (50-65 yr) from the Danish Diet, Cancer, and Health cohort reported physical activity at recruitment (1993-1997) and were followed until 2013 in the National Patient Register for incident hospitalizations for asthma and COPD. Levels of nitrogen dioxide (NO2) were estimated at subject residences at the time of recruitment. We used Cox regression to associate physical activities and NO2 (high/medium/low) with asthma and COPD, and then introduced an interaction term between each physical activity and NO2. MEASUREMENTS AND MAIN RESULTS: A total of 1,151 subjects were hospitalized for asthma and 3,225 for COPD during 16 years. We found inverse associations of participation in sports (hazard ratio [95% confidence interval]: 0.85 [0.75-0.96]) and cycling (0.85 [0.75-0.96]) with incident asthma, and of participation in sports (0.82 [0.77-0.89]), cycling (0.81 [0.76-0.87]), gardening (0.88 [0.81-0.94]), and walking (0.85 [0.75-0.95]) with incident COPD admissions. We found positive associations between NO2 and incident asthma (1.23 [1.04-1.47]) and COPD (1.15 [1.03-1.27]) hospitalizations (comparing ≥21.0 μg/m3 to <14.3 μg/m3). We found no interaction between associations of any physical activity and NO2 on incident asthma or COPD hospitalizations. CONCLUSIONS: Increased exposure to air pollution during exercise does not outweigh beneficial effects of physical activity on the risk of asthma and COPD.
RATIONALE: Physical activity enhances uptake of air pollutants in the lung, possibly augmenting their harmful effects on chronic lung disease during exercise. OBJECTIVES: To examine whether benefits of physical activity with respect to the risk of asthma and chronic obstructive pulmonary disease (COPD) are moderated by exposure to high air pollution levels in an urban setting. METHODS: A total of 53,113 subjects (50-65 yr) from the Danish Diet, Cancer, and Health cohort reported physical activity at recruitment (1993-1997) and were followed until 2013 in the National Patient Register for incident hospitalizations for asthma and COPD. Levels of nitrogen dioxide (NO2) were estimated at subject residences at the time of recruitment. We used Cox regression to associate physical activities and NO2 (high/medium/low) with asthma and COPD, and then introduced an interaction term between each physical activity and NO2. MEASUREMENTS AND MAIN RESULTS: A total of 1,151 subjects were hospitalized for asthma and 3,225 for COPD during 16 years. We found inverse associations of participation in sports (hazard ratio [95% confidence interval]: 0.85 [0.75-0.96]) and cycling (0.85 [0.75-0.96]) with incident asthma, and of participation in sports (0.82 [0.77-0.89]), cycling (0.81 [0.76-0.87]), gardening (0.88 [0.81-0.94]), and walking (0.85 [0.75-0.95]) with incident COPD admissions. We found positive associations between NO2 and incident asthma (1.23 [1.04-1.47]) and COPD (1.15 [1.03-1.27]) hospitalizations (comparing ≥21.0 μg/m3 to <14.3 μg/m3). We found no interaction between associations of any physical activity and NO2 on incident asthma or COPD hospitalizations. CONCLUSIONS: Increased exposure to air pollution during exercise does not outweigh beneficial effects of physical activity on the risk of asthma and COPD.
Authors: Dean E Schraufnagel; John R Balmes; Clayton T Cowl; Sara De Matteis; Soon-Hee Jung; Kevin Mortimer; Rogelio Perez-Padilla; Mary B Rice; Horacio Riojas-Rodriguez; Akshay Sood; George D Thurston; Teresa To; Anessa Vanker; Donald J Wuebbles Journal: Chest Date: 2018-11-09 Impact factor: 9.410
Authors: Charlotte E Sheridan; Charlotte J Roscoe; John Gulliver; Laure de Preux; Daniela Fecht Journal: Int J Environ Res Public Health Date: 2019-09-01 Impact factor: 4.614
Authors: Stephanie Lovinsky-Desir; Kyung Hwa Jung; Jacqueline R Jezioro; David Z Torrone; Mariangels de Planell-Saguer; Beizhan Yan; Frederica P Perera; Andrew G Rundle; Matthew S Perzanowski; Steven N Chillrud; Rachel L Miller Journal: Clin Epigenetics Date: 2017-06-13 Impact factor: 6.551
Authors: Anne Vested; Henrik A Kolstad; Ioannis Basinas; Alex Burdorf; Grethe Elholm; Dick Heederik; Gitte H Jacobsen; Hans Kromhout; Øyvind Omland; Inger Schaumburg; Torben Sigsgaard; Jesper M Vestergaard; Inge M Wouters; Vivi Schlünssen Journal: Scand J Work Environ Health Date: 2020-10-19 Impact factor: 5.024