Literature DB >> 2765373

Drug acetylation in breast cancer.

D J Webster1, D Flook, J Jenkins, A Hutchings, P A Routledge.   

Abstract

The acetylator phenotype was determined in 100 patients with breast cancer and 100 control female subjects using isoniazid. The proportion of fast acetylators in the breast cancer patients (43%) was not significantly different from the control group (43%). We conclude that acetylator phenotype is unlikely to be an important determinant of the risk of developing breast cancer.

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Year:  1989        PMID: 2765373      PMCID: PMC2247050          DOI: 10.1038/bjc.1989.260

Source DB:  PubMed          Journal:  Br J Cancer        ISSN: 0007-0920            Impact factor:   7.640


  7 in total

1.  A simple method for determining acetylator phenotype using isoniazid.

Authors:  A Hutchings; P A Routledge
Journal:  Br J Clin Pharmacol       Date:  1986-09       Impact factor: 4.335

2.  Aberrations of normal development and involution (ANDI): a new perspective on pathogenesis and nomenclature of benign breast disorders.

Authors:  L E Hughes; R E Mansel; D J Webster
Journal:  Lancet       Date:  1987-12-05       Impact factor: 79.321

3.  High-performance liquid chromatographic analysis of isoniazid and acetylisoniazid in biological fluids.

Authors:  A Hutchings; R D Monie; B Spragg; P A Routledge
Journal:  J Chromatogr       Date:  1983-10-14

4.  Determination of acetylator status in uraemia.

Authors:  A Fine; D J Sumner
Journal:  Br J Clin Pharmacol       Date:  1975-10       Impact factor: 4.335

5.  Acetylator phenotype in patients with breast cancer.

Authors:  L N Bulovskaya; R G Krupkin; T A Bochina; A A Shipkova; M V Pavlova
Journal:  Oncology       Date:  1978       Impact factor: 2.935

6.  A method to prevent the loss of isoniazid and acetylisoniazid in human plasma.

Authors:  A Hutchings; R D Monie; B Spragg; P A Routledge
Journal:  Br J Clin Pharmacol       Date:  1983-02       Impact factor: 4.335

7.  Saliva and plasma concentrations of isoniazid and acetylisoniazid in man.

Authors:  A D Hutchings; R D Monie; B P Spragg; P A Routledge
Journal:  Br J Clin Pharmacol       Date:  1988-05       Impact factor: 4.335

  7 in total
  2 in total

Review 1.  Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility.

Authors:  M M de Jong; I M Nolte; G J te Meerman; W T A van der Graaf; J C Oosterwijk; J H Kleibeuker; M Schaapveld; E G E de Vries
Journal:  J Med Genet       Date:  2002-04       Impact factor: 6.318

Review 2.  Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery.

Authors:  E Sim; A Abuhammad; A Ryan
Journal:  Br J Pharmacol       Date:  2014-06       Impact factor: 8.739

  2 in total

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