Literature DB >> 27653600

Germinal Center B Cell Dynamics.

Luka Mesin1, Jonatan Ersching1, Gabriel D Victora2.   

Abstract

Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of affinity maturation. In this review, we discuss recent developments in the field, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27653600      PMCID： PMC5123673          DOI： 10.1016/j.immuni.2016.09.001

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  146 in total

Review 1.  Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.

Authors:  Jason G Cyster; Susan R Schwab
Journal:  Annu Rev Immunol       Date:  2011-12-05       Impact factor: 28.527

2.  Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses.

Authors:  Dominique Gatto; Didrik Paus; Antony Basten; Charles R Mackay; Robert Brink
Journal:  Immunity       Date:  2009-07-16       Impact factor: 31.745

3.  Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts.

Authors:  M Oprea; A S Perelson
Journal:  J Immunol       Date:  1997-06-01       Impact factor: 5.422

4.  Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.

Authors:  Tyani D Chan; Katherine Wood; Jana R Hermes; Danyal Butt; Christopher J Jolly; Antony Basten; Robert Brink
Journal:  Immunity       Date:  2012-11-08       Impact factor: 31.745

Review 5.  Affinity enhancement of antibodies: how low-affinity antibodies produced early in immune responses are followed by high-affinity antibodies later and in memory B-cell responses.

Authors:  Herman N Eisen
Journal:  Cancer Immunol Res       Date:  2014-05       Impact factor: 11.151

6.  Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.

Authors:  Florian Klein; Ron Diskin; Johannes F Scheid; Christian Gaebler; Hugo Mouquet; Ivelin S Georgiev; Marie Pancera; Tongqing Zhou; Reha-Baris Incesu; Brooks Zhongzheng Fu; Priyanthi N P Gnanapragasam; Thiago Y Oliveira; Michael S Seaman; Peter D Kwong; Pamela J Bjorkman; Michel C Nussenzweig
Journal:  Cell       Date:  2013-03-28       Impact factor: 41.582

7.  Maturation of the immune response in germinal centers.

Authors:  C Berek; A Berger; M Apel
Journal:  Cell       Date:  1991-12-20       Impact factor: 41.582

8.  EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.

Authors:  Wendy Béguelin; Relja Popovic; Matt Teater; Yanwen Jiang; Karen L Bunting; Monica Rosen; Hao Shen; Shao Ning Yang; Ling Wang; Teresa Ezponda; Eva Martinez-Garcia; Haikuo Zhang; Yupeng Zheng; Sharad K Verma; Michael T McCabe; Heidi M Ott; Glenn S Van Aller; Ryan G Kruger; Yan Liu; Charles F McHugh; David W Scott; Young Rock Chung; Neil Kelleher; Rita Shaknovich; Caretha L Creasy; Randy D Gascoyne; Kwok-Kin Wong; Leandro Cerchietti; Ross L Levine; Omar Abdel-Wahab; Jonathan D Licht; Olivier Elemento; Ari M Melnick
Journal:  Cancer Cell       Date:  2013-05-13       Impact factor: 31.743

9.  Distinct germinal center selection at local sites shapes memory B cell response to viral escape.

Authors:  Yu Adachi; Taishi Onodera; Yuki Yamada; Rina Daio; Makoto Tsuiji; Takeshi Inoue; Kazuo Kobayashi; Tomohiro Kurosaki; Manabu Ato; Yoshimasa Takahashi
Journal:  J Exp Med       Date:  2015-08-31       Impact factor: 14.307

10.  Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation.

Authors:  Radhika Goenka; Andrew H Matthews; Bochao Zhang; Patrick J O'Neill; Jean L Scholz; Thi-Sau Migone; Warren J Leonard; William Stohl; Uri Hershberg; Michael P Cancro
Journal:  J Exp Med       Date:  2013-12-23       Impact factor: 14.307
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  334 in total

1.  Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface.

Authors:  Mingxing Teng; Scott B Ficarro; Hojong Yoon; Jianwei Che; Jing Zhou; Eric S Fischer; Jarrod A Marto; Tinghu Zhang; Nathanael S Gray
Journal:  ACS Med Chem Lett       Date:  2020-04-03       Impact factor: 4.345

2.  Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase.

Authors:  Jonatan Ersching; Alejo Efeyan; Luka Mesin; Johanne T Jacobsen; Giulia Pasqual; Brian C Grabiner; David Dominguez-Sola; David M Sabatini; Gabriel D Victora
Journal:  Immunity       Date:  2017-06-20       Impact factor: 31.745

3.  Intrinsic properties of human germinal center B cells set antigen affinity thresholds.

Authors:  Kihyuck Kwak; Nicolas Quizon; Haewon Sohn; Avva Saniee; Javier Manzella-Lapeira; Prasida Holla; Joseph Brzostowski; Jinghua Lu; HengYi Xie; Chenguang Xu; Katelyn M Spillane; Pavel Tolar; Susan K Pierce
Journal:  Sci Immunol       Date:  2018-11-30

4.  Mesangial Deposition Can Strongly Involve Innate-Like IgA Molecules Lacking Affinity Maturation.

Authors:  Batoul Wehbi; Christelle Oblet; François Boyer; Arnaud Huard; Anne Druilhe; François Paraf; Etienne Cogné; Jeanne Moreau; Yolla El Makhour; Bassam Badran; Marjolein Van Egmond; Michel Cogné; Jean-Claude Aldigier
Journal:  J Am Soc Nephrol       Date:  2019-06-21       Impact factor: 10.121

5.  Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies.

Authors:  Andrea Bazzoli; David J Vance; Michael J Rudolph; Yinghui Rong; Siva Krishna Angalakurthi; Ronald T Toth; C Russell Middaugh; David B Volkin; David D Weis; John Karanicolas; Nicholas J Mantis
Journal:  Proteins       Date:  2017-08-04

6.  Exacerbated Staphylococcus aureus Foot Infections in Obese/Diabetic Mice Are Associated with Impaired Germinal Center Reactions, Ig Class Switching, and Humoral Immunity.

Authors:  Christopher W Farnsworth; Eric M Schott; Abigail Benvie; Stephen L Kates; Edward M Schwarz; Steven R Gill; Michael J Zuscik; Robert A Mooney
Journal:  J Immunol       Date:  2018-06-01       Impact factor: 5.422

7.  B Cell Receptor Crosslinking Augments Germinal Center B Cell Selection when T Cell Help Is Limiting.

Authors:  Jackson Steed Turner; Fang Ke; Irina Leonidovna Grigorova
Journal:  Cell Rep       Date:  2018-11-06       Impact factor: 9.423

8.  A unique nanoparticulate TLR9 agonist enables a HA split vaccine to confer FcγR-mediated protection against heterologous lethal influenza virus infection.

Authors:  Takuya Yamamoto; Yuji Masuta; Masatoshi Momota; Masaru Kanekiyo; Tomohiro Kanuma; Shoukichi Takahama; Eiko Moriishi; Yasuhiro Yasutomi; Takashi Saito; Barney S Graham; Yoshimasa Takahashi; Ken J Ishii
Journal:  Int Immunol       Date:  2019-02-15       Impact factor: 4.823

9.  Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4.

Authors:  Bi Shi; Jianlin Geng; Yin-Hu Wang; Hairong Wei; Beth Walters; Wei Li; Xuerui Luo; Anna Stevens; Melanie Pittman; Bin Li; Sunnie R Thompson; Hui Hu
Journal:  J Immunol       Date:  2017-12-06       Impact factor: 5.422

10.  TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.

Authors:  Pilar M Dominguez; Hussein Ghamlouch; Wojciech Rosikiewicz; Parveen Kumar; Wendy Béguelin; Lorena Fontán; Martín A Rivas; Patrycja Pawlikowska; Marine Armand; Enguerran Mouly; Miguel Torres-Martin; Ashley S Doane; María T Calvo Fernandez; Matt Durant; Veronique Della-Valle; Matt Teater; Luisa Cimmino; Nathalie Droin; Saber Tadros; Samaneh Motanagh; Alan H Shih; Mark A Rubin; Wayne Tam; Iannis Aifantis; Ross L Levine; Olivier Elemento; Giorgio Inghirami; Michael R Green; Maria E Figueroa; Olivier A Bernard; Said Aoufouchi; Sheng Li; Rita Shaknovich; Ari M Melnick
Journal:  Cancer Discov       Date:  2018-10-01       Impact factor: 39.397
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