Chih-Wei Sung1, Kevin Li-Chun Hsieh2,3, Yun-Ho Lin4,5, Chun-Yi Lin6, Chian-Her Lee6,7, Yang-Hwei Tsuang8,7, Yi-Jie Kuo9,10. 1. School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 2. Department of Medical Imaging, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. 3. Translational Imaging Research Center, College of Medicine, Taipei Medical University, Taipei, Taiwan. 4. Division of Oral Pathology, Department of Dentistry, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. 5. School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. 6. Department of Orthopaedics Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. 7. Department of Orthopaedics Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 8. Department of Orthopaedics Surgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan. 9. Department of Orthopaedics Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. benkuo5@tmu.edu.tw. 10. Department of Orthopaedics Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. benkuo5@tmu.edu.tw.
Abstract
OBJECTIVE: To present a rare case of serous degeneration of bone marrow which resembles primary spinal tumor or bony metastasis to spine. Serous degeneration of bone marrow or gelatinous marrow transformation is a rare disease characterized by focal marrow hypoplasia, fat atrophy, and accumulation of extracellular mucopolysaccharides abundant in hyaluronic acid. Few literature was reviewed and few clinical case was presented. METHODS: Two cases of serous marrow transformation were reported. RESULTS: In the first case, a 29-year-old man suffered from severe left buttock pain. Bone metastasis was impressed in radiology examinations. Percutaneous endoscopic lumbar discectomy was performed along with bone biopsy. In the second case, a 49-year-old man presented lower back pain with radiation to bilateral lower legs. Magnetic resonance imaging revealed a water-like signal lesion in sacrum. Serous marrow transformation was confirmed pathologically in both cases. CONCLUSION: To the best of our knowledge, a case of serous degeneration of bone marrow resembling malignancy has not been reported in the literature. In this report, two cases demonstrate serous transformation of bone marrow mimics spinal tumor.
OBJECTIVE: To present a rare case of serous degeneration of bone marrow which resembles primary spinal tumor or bony metastasis to spine. Serous degeneration of bone marrow or gelatinous marrow transformation is a rare disease characterized by focal marrow hypoplasia, fat atrophy, and accumulation of extracellular mucopolysaccharides abundant in hyaluronic acid. Few literature was reviewed and few clinical case was presented. METHODS: Two cases of serous marrow transformation were reported. RESULTS: In the first case, a 29-year-old man suffered from severe left buttock pain. Bone metastasis was impressed in radiology examinations. Percutaneous endoscopic lumbar discectomy was performed along with bone biopsy. In the second case, a 49-year-old man presented lower back pain with radiation to bilateral lower legs. Magnetic resonance imaging revealed a water-like signal lesion in sacrum. Serous marrow transformation was confirmed pathologically in both cases. CONCLUSION: To the best of our knowledge, a case of serous degeneration of bone marrow resembling malignancy has not been reported in the literature. In this report, two cases demonstrate serous transformation of bone marrow mimics spinal tumor.
Authors: Ana I García; Ana Milinkovic; Xavier Tomás; José Rios; Iñaki Pérez; Sergi Vidal-Sicart; Jaume Pomés; Montserrat Del Amo; Josep Mallolas Journal: Skeletal Radiol Date: 2011-04-10 Impact factor: 2.199
Authors: Kirsten Ecklund; Sridhar Vajapeyam; Henry A Feldman; Catherine D Buzney; Robert V Mulkern; Paul K Kleinman; Clifford J Rosen; Catherine M Gordon Journal: J Bone Miner Res Date: 2010-02 Impact factor: 6.741