Human salivary protein interaction with fluoridated synthetic hydroxyapatite.

Adsorption of human salivary protein on synthetic hydroxyapatite after fluoridation of the mineral phase was tested using an experimental system previously described. The salivary protein adsorption on fluoridated apatite was considerably decreased compared to the adsorption obtained with untreated hydroxyapatite. The calcium-precipitable human salivary glycoprotein still seemed to be selectively adsorbed. Liberation of fluoride under the effect of the salivary proteins was also observed. Fluoridation of enamel may decrease pellicle formation with competitive adsorption effect between salivary proteins and fluoride.