Literature DB >> 27652318

Asymmetric division: An antitumor player?

Lihua Wang1, Pengcheng Bu2, Xiling Shen3.   

Abstract

miR-34a-mediated asymmetric cell division reins in excessive stem cell expansion during tissue regeneration in the intestine and colon. Loss of miR-34a switches asymmetric division to symmetric division and enhances stem cell proliferation. Asymmetric division also occurs in the early stages of colon cancer stem cells. Mechanistically, miR-34a, Numb, and Notch form a feed-forward loop that specifies cell fate when stem cells divide.

Entities:  

Year:  2016        PMID： 27652318      PMCID： PMC4972103          DOI： 10.1080/23723556.2016.1164279

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.

Authors:  Hugo J Snippert; Laurens G van der Flier; Toshiro Sato; Johan H van Es; Maaike van den Born; Carla Kroon-Veenboer; Nick Barker; Allon M Klein; Jacco van Rheenen; Benjamin D Simons; Hans Clevers
Journal:  Cell       Date:  2010-10-01       Impact factor: 41.582

2.  Stem cells, asymmetric division and cancer.

Authors:  Hans Clevers
Journal:  Nat Genet       Date:  2005-10       Impact factor: 38.330

3.  Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

Authors:  Johan H van Es; Marielle E van Gijn; Orbicia Riccio; Maaike van den Born; Marc Vooijs; Harry Begthel; Miranda Cozijnsen; Sylvie Robine; Doug J Winton; Freddy Radtke; Hans Clevers
Journal:  Nature       Date:  2005-06-16       Impact factor: 49.962

4.  MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells.

Authors:  Wei-Lun Hwang; Jeng-Kae Jiang; Shung-Haur Yang; Tse-Shun Huang; Hsin-Yi Lan; Hao-Wei Teng; Chih-Yung Yang; Ya-Ping Tsai; Chi-Hung Lin; Hsei-Wei Wang; Muh-Hwa Yang
Journal:  Nat Cell Biol       Date:  2014-03       Impact factor: 28.824

Review 5.  p53 enters the microRNA world.

Authors:  Heiko Hermeking
Journal:  Cancer Cell       Date:  2007-11       Impact factor: 31.743

6.  Crypt stem cells as the cells-of-origin of intestinal cancer.

Authors:  Nick Barker; Rachel A Ridgway; Johan H van Es; Marc van de Wetering; Harry Begthel; Maaike van den Born; Esther Danenberg; Alan R Clarke; Owen J Sansom; Hans Clevers
Journal:  Nature       Date:  2008-12-17       Impact factor: 49.962

7.  A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells.

Authors:  Pengcheng Bu; Kai-Yuan Chen; Joyce Huan Chen; Lihua Wang; Jewell Walters; Yong Jun Shin; Julian P Goerger; Jian Sun; Mavee Witherspoon; Nikolai Rakhilin; Jiahe Li; Herman Yang; Jeff Milsom; Sang Lee; Warren Zipfel; Moonsoo M Jin; Zeynep H Gümüş; Steven M Lipkin; Xiling Shen
Journal:  Cell Stem Cell       Date:  2013-05-02       Impact factor: 24.633

8.  A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer.

Authors:  Pengcheng Bu; Lihua Wang; Kai-Yuan Chen; Tara Srinivasan; Preetish Kadur Lakshminarasimha Murthy; Kuei-Ling Tung; Anastasia Kristine Varanko; Huanhuan Joyce Chen; Yiwei Ai; Sarah King; Steven M Lipkin; Xiling Shen
Journal:  Cell Stem Cell       Date:  2016-02-04       Impact factor: 24.633

9.  miR-34 miRNAs provide a barrier for somatic cell reprogramming.

Authors:  Yong Jin Choi; Chao-Po Lin; Jaclyn J Ho; Xingyue He; Nobuhiro Okada; Pengcheng Bu; Yingchao Zhong; Sang Yong Kim; Margaux J Bennett; Caifu Chen; Arzu Ozturk; Geoffrey G Hicks; Greg J Hannon; Lin He
Journal:  Nat Cell Biol       Date:  2011-10-23       Impact factor: 28.824

10.  The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44.

Authors:  Can Liu; Kevin Kelnar; Bigang Liu; Xin Chen; Tammy Calhoun-Davis; Hangwen Li; Lubna Patrawala; Hong Yan; Collene Jeter; Sofia Honorio; Jason F Wiggins; Andreas G Bader; Randy Fagin; David Brown; Dean G Tang
Journal:  Nat Med       Date:  2011-01-16       Impact factor: 53.440
  10 in total
  3 in total

1.  Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients.

Authors:  Cristiano Farace; Andrea Pisano; Carmen Griñan-Lison; Juan Antonio Marchal; Roberto Madeddu; Giuliana Solinas; Gema Jiménez; Marina Serra; Esmeralda Carrillo; Fabrizio Scognamillo; Federico Attene; Andrea Montella
Journal:  Oncotarget       Date:  2020-01-14

2.  Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study.

Authors:  Sinem Cil Gonulcu; Betul Unal; Ibrahim Cumhur Bassorgun; Mualla Ozcan; Hasan Senol Coskun; Gulsum Ozlem Elpek
Journal:  World J Gastroenterol       Date:  2020-07-14       Impact factor: 5.742

3.  Evodiamine Eliminates Colon Cancer Stem Cells via Suppressing Notch and Wnt Signaling.

Authors:  Hyejin Kim; Yeongji Yu; SeokGyeong Choi; Hani Lee; Jinsuh Yu; Jeong-Ho Lee; Woo-Young Kim
Journal:  Molecules       Date:  2019-12-10       Impact factor: 4.411
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.