Literature DB >> 27652315

Demystifying the role of mitochondria in senescence.

Clara Correia-Melo1, João F Passos1.   

Abstract

In a study published in The EMBO Journal, we demonstrated that mitochondria are necessary for the proinflammatory phenotype of senescence. Furthermore, we identified a new senescence-regulatory pathway involving mTOR-dependent mitochondrial biogenesis. These data highlight mitochondria as targets for interventions that counteract the pro-aging effects of senescence while preserving tumor suppression.

Entities:  

Keywords:  Ageing; mTOR; mitochondria; senescence

Year:  2016        PMID： 27652315      PMCID： PMC4972119          DOI： 10.1080/23723556.2016.1162896

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  The role of senescent cells in ageing.

Authors:  Jan M van Deursen
Journal:  Nature       Date:  2014-05-22       Impact factor: 49.962

2.  MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.

Authors:  Remi-Martin Laberge; Yu Sun; Arturo V Orjalo; Christopher K Patil; Adam Freund; Lili Zhou; Samuel C Curran; Albert R Davalos; Kathleen A Wilson-Edell; Su Liu; Chandani Limbad; Marco Demaria; Patrick Li; Gene B Hubbard; Yuji Ikeno; Martin Javors; Pierre-Yves Desprez; Christopher C Benz; Pankaj Kapahi; Peter S Nelson; Judith Campisi
Journal:  Nat Cell Biol       Date:  2015-07-06       Impact factor: 28.824

3.  Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype.

Authors:  Christopher D Wiley; Michael C Velarde; Pacome Lecot; Su Liu; Ethan A Sarnoski; Adam Freund; Kotaro Shirakawa; Hyung W Lim; Sonnet S Davis; Arvind Ramanathan; Akos A Gerencser; Eric Verdin; Judith Campisi
Journal:  Cell Metab       Date:  2015-12-10       Impact factor: 27.287

4.  A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

Authors:  Joanna Kaplon; Liang Zheng; Katrin Meissl; Barbara Chaneton; Vitaly A Selivanov; Gillian Mackay; Sjoerd H van der Burg; Elizabeth M E Verdegaal; Marta Cascante; Tomer Shlomi; Eyal Gottlieb; Daniel S Peeper
Journal:  Nature       Date:  2013-05-19       Impact factor: 49.962

Review 5.  Mitochondria: Are they causal players in cellular senescence?

Authors:  Clara Correia-Melo; João F Passos
Journal:  Biochim Biophys Acta       Date:  2015-05-28

6.  Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

Authors:  Graeme Hewitt; Diana Jurk; Francisco D M Marques; Clara Correia-Melo; Timothy Hardy; Agata Gackowska; Rhys Anderson; Morgan Taschuk; Jelena Mann; João F Passos
Journal:  Nat Commun       Date:  2012-02-28       Impact factor: 14.919

7.  Feedback between p21 and reactive oxygen production is necessary for cell senescence.

Authors:  João F Passos; Glyn Nelson; Chunfang Wang; Torsten Richter; Cedric Simillion; Carole J Proctor; Satomi Miwa; Sharon Olijslagers; Jennifer Hallinan; Anil Wipat; Gabriele Saretzki; Karl Lenhard Rudolph; Tom B L Kirkwood; Thomas von Zglinicki
Journal:  Mol Syst Biol       Date:  2010-02-16       Impact factor: 11.429

8.  Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.

Authors:  Derek Narendra; Atsushi Tanaka; Der-Fen Suen; Richard J Youle
Journal:  J Cell Biol       Date:  2008-11-24       Impact factor: 10.539

9.  Mitochondria are required for pro-ageing features of the senescent phenotype.

Authors:  Clara Correia-Melo; Francisco D M Marques; Rhys Anderson; Graeme Hewitt; Rachael Hewitt; John Cole; Bernadette M Carroll; Satomi Miwa; Jodie Birch; Alina Merz; Michael D Rushton; Michelle Charles; Diana Jurk; Stephen W G Tait; Rafal Czapiewski; Laura Greaves; Glyn Nelson; Mohammad Bohlooly-Y; Sergio Rodriguez-Cuenca; Antonio Vidal-Puig; Derek Mann; Gabriele Saretzki; Giovanni Quarato; Douglas R Green; Peter D Adams; Thomas von Zglinicki; Viktor I Korolchuk; João F Passos
Journal:  EMBO J       Date:  2016-02-04       Impact factor: 11.598

10.  mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Authors:  Nicolás Herranz; Suchira Gallage; Massimiliano Mellone; Torsten Wuestefeld; Sabrina Klotz; Christopher J Hanley; Selina Raguz; Juan Carlos Acosta; Andrew J Innes; Ana Banito; Athena Georgilis; Alex Montoya; Katharina Wolter; Gopuraja Dharmalingam; Peter Faull; Thomas Carroll; Juan Pedro Martínez-Barbera; Pedro Cutillas; Florian Reisinger; Mathias Heikenwalder; Richard A Miller; Dominic Withers; Lars Zender; Gareth J Thomas; Jesús Gil
Journal:  Nat Cell Biol       Date:  2015-08-17       Impact factor: 28.824
  10 in total
  3 in total

1.  Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.

Authors:  Meera V Singh; Sivareddy Kotla; Nhat-Tu Le; Kyung Ae Ko; Kyung-Sun Heo; Yin Wang; Yuka Fujii; Hang Thi Vu; Elena McBeath; Tamlyn N Thomas; Young Jin Gi; Yunting Tao; Jan L Medina; Jack Taunton; Nancy Carson; Vikram Dogra; Marvin M Doyley; Alicia Tyrell; Wang Lu; Xing Qiu; Nicole E Stirpe; Kathleen J Gates; Christine Hurley; Keigi Fujiwara; Sanjay B Maggirwar; Giovanni Schifitto; Jun-Ichi Abe
Journal:  Circulation       Date:  2019-02-26       Impact factor: 29.690

2.  DNA repair after oxidative stress: current challenges.

Authors:  Bennett Van Houten; Gloria A Santa-Gonzalez; Mauricio Camargo
Journal:  Curr Opin Toxicol       Date:  2017-10-16

Review 3.  Mechanisms and Regulation of Cellular Senescence.

Authors:  Lauréline Roger; Fanny Tomas; Véronique Gire
Journal:  Int J Mol Sci       Date:  2021-12-06       Impact factor: 5.923
  3 in total

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