Yoriyasu Suzuki1, Makoto Muto2, Masahisa Yamane3, Toshiya Muramatsu4, Atsunori Okamura5, Yasumi Igarashi6, Tsutomu Fujita7, Shigeru Nakamura8, Akitsugu Oida9, Etsuo Tsuchikane10. 1. Division of Cardiovascular Medicine, Nagoya Heart Center, Aichi, Japan. 2. Division of Cardiology, Saitama Prefecture Cardiovascular and Respiratory Center, Saitama, Japan. 3. Cardiology Department, Saitama Sekishinkai Hospital, Saitama, Japan. 4. Department of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Kanagawa, Japan. 5. Division Of Cardiology, Sakurabashi-Watanabe Hospital, Osaka, Japan. 6. Cardiovascular Center, Japan Community Health care Organization Hokkaido Hosptal, Hokkaido, Japan. 7. Division of Cardiology, Sapporo Cardiovascular Clinic, Hokkaido, Japan. 8. Cardiovascular Center, Kyoto Katsura Hospital, Kyoto, Japan. 9. Department of Cardiology, Takase Clinic, Gunma, Japan. 10. Department of Cardiology, Toyohashi Heart Center, Aichi, Japan.
Abstract
OBJECTIVES: To evaluate factors for predicting retrograde CTO-PCI failure after successful collateral channel crossing. BACKGROUND: Successful guidewire/catheter collateral channel crossing is important for the retrograde approach in percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). METHODS: A total of 5984 CTO-PCI procedures performed in 45 centers in Japan from 2009 to 2012 were studied. The retrograde approach was used in 1656 CTO-PCIs (27.7%). We investigated these retrograde procedures to evaluate factors for predicting retrograde CTO-PCI failure even after successful collateral channel crossing. RESULTS: Successful guidewire/catheter collateral crossing was achieved in 77.1% (n = 1,276) of 1656 retrograde CTO-PCI procedures. Retrograde procedural success after successful collateral crossing was achieved in 89.4% (n = 1,141). Univariate analysis showed that the predictors for retrograde CTO-PCI failure were in-stent occlusion (OR = 1.9829, 95%CI = 1.1783 - 3.3370 P = 0.0088), calcified lesions (OR = 1.9233, 95%CI = 1.2463 - 2.9679, P = 0.0027), and lesion tortuosity (OR = 1.5244, 95%CI = 1.0618 - 2.1883, P = 0.0216). On multivariate analysis, lesion calcification was an independent predictor of retrograde CTO-PCI failure after successful collateral channel crossing (OR = 1.3472, 95%CI = 1.0614 - 1.7169, P = 0.0141). CONCLUSIONS: The success rate of retrograde CTO-PCI following successful guidewire/catheter collateral channel crossing was high in this registry. Lesion calcification was an independent predictor of retrograde CTO-PCI failure after successful collateral channel crossing. Devices and techniques to overcome complex CTO lesion morphology, such as lesion calcification, are required to further improve the retrograde CTO-PCI success rate.
OBJECTIVES: To evaluate factors for predicting retrograde CTO-PCI failure after successful collateral channel crossing. BACKGROUND: Successful guidewire/catheter collateral channel crossing is important for the retrograde approach in percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). METHODS: A total of 5984 CTO-PCI procedures performed in 45 centers in Japan from 2009 to 2012 were studied. The retrograde approach was used in 1656 CTO-PCIs (27.7%). We investigated these retrograde procedures to evaluate factors for predicting retrograde CTO-PCI failure even after successful collateral channel crossing. RESULTS: Successful guidewire/catheter collateral crossing was achieved in 77.1% (n = 1,276) of 1656 retrograde CTO-PCI procedures. Retrograde procedural success after successful collateral crossing was achieved in 89.4% (n = 1,141). Univariate analysis showed that the predictors for retrograde CTO-PCI failure were in-stent occlusion (OR = 1.9829, 95%CI = 1.1783 - 3.3370 P = 0.0088), calcified lesions (OR = 1.9233, 95%CI = 1.2463 - 2.9679, P = 0.0027), and lesion tortuosity (OR = 1.5244, 95%CI = 1.0618 - 2.1883, P = 0.0216). On multivariate analysis, lesion calcification was an independent predictor of retrograde CTO-PCI failure after successful collateral channel crossing (OR = 1.3472, 95%CI = 1.0614 - 1.7169, P = 0.0141). CONCLUSIONS: The success rate of retrograde CTO-PCI following successful guidewire/catheter collateral channel crossing was high in this registry. Lesion calcification was an independent predictor of retrograde CTO-PCI failure after successful collateral channel crossing. Devices and techniques to overcome complex CTO lesion morphology, such as lesion calcification, are required to further improve the retrograde CTO-PCI success rate.