Firas Rinawi1, Imad Kassis2,3, Rina Tamir3, Amir Kugelman3,4, Isaac Srugo3,4, Dan Miron3,5. 1. Pediatric Department A', HaEmeq Medical Center, POB 10535, 16100, Afula, Israel. firasri@clalit.org.il. 2. Pediatric Infectious Disease unit, Meyer Children Hospital, Haifa, Israel. 3. The Ruth and Bruce Rappaport School of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. 4. Pediatric Department, Bnai Zion Medical Center, Haifa, Israel. 5. Pediatric Infectious Disease Consultation Service, HaEmeq Medical Center, Afula, Israel.
Abstract
BACKGROUND: Acute bronchiolitis in infancy is considered a risk factor for recurrent wheezing episodes in childhood. The present study assessed prevalence, clinical manifestations and risk factors for recurrent wheezing events during the first 3 years of life and persistent wheezing events beyond this age in children hospitalized as young infants with acute bronchiolitis. METHODS: Two groups of children aged 6 years were included. The study group comprised 150 children with a history of hospitalization for bronchiolitis, with the first event at <6 months of age. The control group comprised 66 age- and sex-matched children with no history of bronchiolitis before 6 months of age. Children in both groups had been followed until 6 years of age by their pediatricians; data were obtained retrospectively by reviewing ambulatory records during children's visits in pediatricians' clinics. The data included epidemiological parameters, prevalence, age at onset, number of and treatments given for episodes of wheezing events prior to 6 years of age, pathogens detected, and severity of acute bronchiolitis in the study group. RESULTS: Overall, 58% and 27% of children in the study and control groups, respectively (P=0.001) had recurrent wheezing episodes prior to the age of 3 years. Children in the study group had earlier onset of recurrent wheezing, had more episodes of wheezing, and required more bronchodilator and systemic steroids treatments compared to the control group. CONCLUSION: Hospitalization within the first six months of life for acute bronchiolitis is an independent risk factor for recurrent wheezing episodes during the first 3 years of life.
BACKGROUND:Acute bronchiolitis in infancy is considered a risk factor for recurrent wheezing episodes in childhood. The present study assessed prevalence, clinical manifestations and risk factors for recurrent wheezing events during the first 3 years of life and persistent wheezing events beyond this age in children hospitalized as young infants with acute bronchiolitis. METHODS: Two groups of children aged 6 years were included. The study group comprised 150 children with a history of hospitalization for bronchiolitis, with the first event at <6 months of age. The control group comprised 66 age- and sex-matched children with no history of bronchiolitis before 6 months of age. Children in both groups had been followed until 6 years of age by their pediatricians; data were obtained retrospectively by reviewing ambulatory records during children's visits in pediatricians' clinics. The data included epidemiological parameters, prevalence, age at onset, number of and treatments given for episodes of wheezing events prior to 6 years of age, pathogens detected, and severity of acute bronchiolitis in the study group. RESULTS: Overall, 58% and 27% of children in the study and control groups, respectively (P=0.001) had recurrent wheezing episodes prior to the age of 3 years. Children in the study group had earlier onset of recurrent wheezing, had more episodes of wheezing, and required more bronchodilator and systemic steroids treatments compared to the control group. CONCLUSION: Hospitalization within the first six months of life for acute bronchiolitis is an independent risk factor for recurrent wheezing episodes during the first 3 years of life.
Entities:
Keywords:
acute bronchiolitis; recurrent wheezing; young infants
Authors: L Bont; C J Heijnen; A Kavelaars; W M van Aalderen; F Brus; J T Draaisma; S M Geelen; J L Kimpen Journal: Am J Respir Crit Care Med Date: 2000-05 Impact factor: 21.405
Authors: Shawn L Ralston; Allan S Lieberthal; H Cody Meissner; Brian K Alverson; Jill E Baley; Anne M Gadomski; David W Johnson; Michael J Light; Nizar F Maraqa; Eneida A Mendonca; Kieran J Phelan; Joseph J Zorc; Danette Stanko-Lopp; Mark A Brown; Ian Nathanson; Elizabeth Rosenblum; Stephen Sayles; Sinsi Hernandez-Cancio Journal: Pediatrics Date: 2014-11 Impact factor: 7.124
Authors: E Bamberger; I Srugo; B Abu Raya; E Segal; B Chaim; I Kassis; A Kugelman; D Miron Journal: Eur J Clin Microbiol Infect Dis Date: 2012-07-24 Impact factor: 3.267
Authors: K Grimwood; C Cohet; F J Rich; S Cheng; C Wood; N Redshaw; C W Cunningham; N Pearce; J R Kirman Journal: Epidemiol Infect Date: 2008-01-04 Impact factor: 2.451
Authors: Amanda J Driscoll; S Hasan Arshad; Louis Bont; Steven M Brunwasser; Thomas Cherian; Janet A Englund; Deshayne B Fell; Laura L Hammitt; Tina V Hartert; Bruce L Innis; Ruth A Karron; Gayle E Langley; E Kim Mulholland; Patrick K Munywoki; Harish Nair; Justin R Ortiz; David A Savitz; Nienke M Scheltema; Eric A F Simões; Peter G Smith; Fred Were; Heather J Zar; Daniel R Feikin Journal: Vaccine Date: 2020-01-20 Impact factor: 3.641