Erik Landfeldt1, Anna Castelo-Branco2, Axel Svedbom2, Emil Löfroth3, Andrius Kavaliunas4, Jan Hillert4. 1. Mapi Group, Stockholm, Sweden/Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden erik.landfeldt@ki.se. 2. Mapi Group, Stockholm, Sweden. 3. Novartis, Stockholm, Sweden. 4. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Abstract
BACKGROUND: Multiple sclerosis (MS) is associated with considerable morbidity and serious disability, but little is known of the long-term impact of the disease on work ability. OBJECTIVES: To assess sick leave (short-term absence) and disability pension (long-term absence) before and after diagnosis of MS. METHODS: Patients with MS in Sweden were identified in a nationwide disease-specific register and matched with general population controls. Sick leave and disability pension were measured before and after index (i.e. the MS diagnosis date). RESULTS: The final sample comprised 6092 patients and 60,345 controls (mean age 39 years; 70% female). The mean annual prevalence of sick leave ranged from 12% the first year after index to 23% after 11 years among patients and from 13% to 13% among controls. Corresponding estimates for disability pension were 12% and 55% for patients and 7% and 9% for controls. Significant differences in sick leave were observed up to 15 years before index and 3 years for disability pension. CONCLUSION: Patients with MS in Sweden have elevated levels of sick leave and disability pension up to 15 years before disease diagnosis. Our results highlight the burden of disease on affected patients and society and underscore the substantial unmet medical need.
BACKGROUND:Multiple sclerosis (MS) is associated with considerable morbidity and serious disability, but little is known of the long-term impact of the disease on work ability. OBJECTIVES: To assess sick leave (short-term absence) and disability pension (long-term absence) before and after diagnosis of MS. METHODS:Patients with MS in Sweden were identified in a nationwide disease-specific register and matched with general population controls. Sick leave and disability pension were measured before and after index (i.e. the MS diagnosis date). RESULTS: The final sample comprised 6092 patients and 60,345 controls (mean age 39 years; 70% female). The mean annual prevalence of sick leave ranged from 12% the first year after index to 23% after 11 years among patients and from 13% to 13% among controls. Corresponding estimates for disability pension were 12% and 55% for patients and 7% and 9% for controls. Significant differences in sick leave were observed up to 15 years before index and 3 years for disability pension. CONCLUSION:Patients with MS in Sweden have elevated levels of sick leave and disability pension up to 15 years before disease diagnosis. Our results highlight the burden of disease on affected patients and society and underscore the substantial unmet medical need.
Authors: Andrius Kavaliunas; Ali Manouchehrinia; Hanna Gyllensten; Kristina Alexanderson; Jan Hillert Journal: Mult Scler J Exp Transl Clin Date: 2020-10-07
Authors: Astrid R Bosma; Chantelle Murley; Jenny Aspling; Jan Hillert; Frederieke G Schaafsma; Johannes R Anema; Cécile R L Boot; Kristina Alexanderson; Alejandra Machado; Emilie Friberg Journal: Mult Scler Date: 2021-10-06 Impact factor: 5.855
Authors: Erik Landfeldt; Anna Castelo-Branco; Axel Svedbom; Emil Löfroth; Andrius Kavaliunas; Jan Hillert Journal: J Neurol Date: 2018-02-01 Impact factor: 4.849