| Literature DB >> 2764971 |
S Tanuma1, H Sakagami, H Endo.
Abstract
Tannin, a naturally occurring polyphenolic compound, was found to inhibit the activity of purified poly(ADP-ribose) glycohydrolase from human placenta. The inhibition was dose-dependent and half maximal with 2.8 micrograms/ml of tannin. The inhibitory effect of tannin was two and three orders of magnitude more than those of ADP-ribose and cAMP, respectively. Kinetic analysis revealed that the inhibition by tannin was competitive with respect to the substrate poly(ADP-ribose).Entities:
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Year: 1989 PMID： 2764971
Source DB: PubMed Journal: Biochem Int ISSN： 0158-5231