Literature DB >> 27649053

Transcriptional kinases: Caught by a sticky drug.

Dalibor Blazek1.   

Abstract

Year:  2016        PMID： 27649053     DOI： 10.1038/nchembio.2184

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  10 in total

1.  CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.

Authors:  Bartlomiej Bartkowiak; Pengda Liu; Hemali P Phatnani; Nicholas J Fuda; Jeffrey J Cooper; David H Price; Karen Adelman; John T Lis; Arno L Greenleaf
Journal:  Genes Dev       Date:  2010-10-15       Impact factor: 11.361

2.  Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.

Authors:  Tinghu Zhang; Nicholas Kwiatkowski; Calla M Olson; Sarah E Dixon-Clarke; Brian J Abraham; Ann K Greifenberg; Scott B Ficarro; Jonathan M Elkins; Yanke Liang; Nancy M Hannett; Theresa Manz; Mingfeng Hao; Bartlomiej Bartkowiak; Arno L Greenleaf; Jarrod A Marto; Matthias Geyer; Alex N Bullock; Richard A Young; Nathanael S Gray
Journal:  Nat Chem Biol       Date:  2016-08-29       Impact factor: 15.040

3.  Structural and Functional Analysis of the Cdk13/Cyclin K Complex.

Authors:  Ann Katrin Greifenberg; Dana Hönig; Kveta Pilarova; Robert Düster; Koen Bartholomeeusen; Christian A Bösken; Kanchan Anand; Dalibor Blazek; Matthias Geyer
Journal:  Cell Rep       Date:  2015-12-31       Impact factor: 9.423

Review 4.  Defining mechanisms that regulate RNA polymerase II transcription in vivo.

Authors:  Nicholas J Fuda; M Behfar Ardehali; John T Lis
Journal:  Nature       Date:  2009-09-10       Impact factor: 49.962

5.  The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

Authors:  Dalibor Blazek; Jiri Kohoutek; Koen Bartholomeeusen; Eric Johansen; Petra Hulinkova; Zeping Luo; Peter Cimermancic; Jernej Ule; B Matija Peterlin
Journal:  Genes Dev       Date:  2011-10-15       Impact factor: 11.361

6.  Integrated genomic analyses of ovarian carcinoma.

Authors: 
Journal:  Nature       Date:  2011-06-29       Impact factor: 49.962

7.  Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Authors:  Nicholas Kwiatkowski; Tinghu Zhang; Peter B Rahl; Brian J Abraham; Jessica Reddy; Scott B Ficarro; Anahita Dastur; Arnaud Amzallag; Sridhar Ramaswamy; Bethany Tesar; Catherine E Jenkins; Nancy M Hannett; Douglas McMillin; Takaomi Sanda; Taebo Sim; Nam Doo Kim; Thomas Look; Constantine S Mitsiades; Andrew P Weng; Jennifer R Brown; Cyril H Benes; Jarrod A Marto; Richard A Young; Nathanael S Gray
Journal:  Nature       Date:  2014-06-22       Impact factor: 49.962

8.  RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.

Authors:  Ming Yu; Wenjing Yang; Ting Ni; Zhanyun Tang; Tomoyoshi Nakadai; Jun Zhu; Robert G Roeder
Journal:  Science       Date:  2015-12-11       Impact factor: 47.728

9.  Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.

Authors:  Ilirjana Bajrami; Jessica R Frankum; Asha Konde; Rowan E Miller; Farah L Rehman; Rachel Brough; James Campbell; David Sims; Rumana Rafiq; Sean Hooper; Lina Chen; Iwanka Kozarewa; Ioannis Assiotis; Kerry Fenwick; Rachael Natrajan; Christopher J Lord; Alan Ashworth
Journal:  Cancer Res       Date:  2013-11-15       Impact factor: 12.701

10.  Proteogenomics connects somatic mutations to signalling in breast cancer.

Authors:  Philipp Mertins; D R Mani; Kelly V Ruggles; Michael A Gillette; Karl R Clauser; Pei Wang; Xianlong Wang; Jana W Qiao; Song Cao; Francesca Petralia; Emily Kawaler; Filip Mundt; Karsten Krug; Zhidong Tu; Jonathan T Lei; Michael L Gatza; Matthew Wilkerson; Charles M Perou; Venkata Yellapantula; Kuan-lin Huang; Chenwei Lin; Michael D McLellan; Ping Yan; Sherri R Davies; R Reid Townsend; Steven J Skates; Jing Wang; Bing Zhang; Christopher R Kinsinger; Mehdi Mesri; Henry Rodriguez; Li Ding; Amanda G Paulovich; David Fenyö; Matthew J Ellis; Steven A Carr
Journal:  Nature       Date:  2016-05-25       Impact factor: 49.962
  10 in total

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