Literature DB >> 2764892

The Streptomyces K15 DD-peptidase/penicillin-binding protein. Active site and sequence of the N-terminal region.

M Leyh-Bouille1, J Van Beeumen, S Renier-Pirlot, B Joris, M Nguyen-Distèche, J M Ghuysen.   

Abstract

The N-terminal region of the Streptomyces K15 DD-peptidase/penicillin-binding protein shows high homology with that of other penicillin-interactive proteins or domains. The active-site serine residue of the conserved tetrad Ser-Xaa-Xaa-Lys occurs at position 35. There is no indication for the presence of a signal peptide or an N-terminal hydrophobic sequence, suggesting that the Streptomyces K15 enzyme is probably anchored to the membrane by a C-terminal peptide segment.

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Year:  1989        PMID： 2764892      PMCID： PMC1138712          DOI： 10.1042/bj2600601

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

1.  Reduced heat resistance of mutant spores after cloning and mutagenesis of the Bacillus subtilis gene encoding penicillin-binding protein 5.

Authors:  J A Todd; A N Roberts; K Johnstone; P J Piggot; G Winter; D J Ellar
Journal:  J Bacteriol       Date:  1986-07       Impact factor: 3.490

2.  Effects of thiol reagents on Streptomyces K15 DD-peptidase-catalysed reactions.

Authors:  M Leyh-Bouille; M Nguyen-Distèche; C Bellefroid-Bourguignon; J M Ghuysen
Journal:  Biochem J       Date:  1987-02-01       Impact factor: 3.857

3.  Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion.

Authors:  M D Song; M Wachi; M Doi; F Ishino; M Matsuhashi
Journal:  FEBS Lett       Date:  1987-08-31       Impact factor: 4.124

4.  Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae.

Authors:  B G Spratt
Journal:  Nature       Date:  1988-03-10       Impact factor: 49.962

5.  Primary structure of the Streptomyces R61 extracellular DD-peptidase. 1. Cloning into Streptomyces lividans and nucleotide sequence of the gene.

Authors:  C Duez; C Piron-Fraipont; B Joris; J Dusart; M S Urdea; J A Martial; J M Frère; J M Ghuysen
Journal:  Eur J Biochem       Date:  1987-02-02

6.  Nucleotide sequence of the pbpA gene and characteristics of the deduced amino acid sequence of penicillin-binding protein 2 of Escherichia coli K12.

Authors:  S Asoh; H Matsuzawa; F Ishino; J L Strominger; M Matsuhashi; T Ohta
Journal:  Eur J Biochem       Date:  1986-10-15

7.  Properties and crystallization of a genetically engineered, water-soluble derivative of penicillin-binding protein 5 of Escherichia coli K12.

Authors:  L C Ferreira; U Schwarz; W Keck; P Charlier; O Dideberg; J M Ghuysen
Journal:  Eur J Biochem       Date:  1988-01-15

8.  Streptomyces K15 DD-peptidase-catalysed reactions with ester and amide carbonyl donors.

Authors:  M Nguyen-Distèche; M Leyh-Bouille; S Pirlot; J M Frère; J M Ghuysen
Journal:  Biochem J       Date:  1986-04-01       Impact factor: 3.857

9.  The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 DD-peptidase family.

Authors:  B Joris; J M Ghuysen; G Dive; A Renard; O Dideberg; P Charlier; J M Frère; J A Kelly; J C Boyington; P C Moews
Journal:  Biochem J       Date:  1988-03-01       Impact factor: 3.857

10.  The C terminus of penicillin-binding protein 5 is essential for localisation to the E. coli inner membrane.

Authors:  J M Pratt; M E Jackson; I B Holland
Journal:  EMBO J       Date:  1986-09       Impact factor: 11.598
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  1 in total

1.  Amino acid sequence of the penicillin-binding protein/DD-peptidase of Streptomyces K15. Predicted secondary structures of the low Mr penicillin-binding proteins of class A.

Authors:  P Palomeque-Messia; S Englebert; M Leyh-Bouille; M Nguyen-Distèche; C Duez; S Houba; O Dideberg; J Van Beeumen; J M Ghuysen
Journal:  Biochem J       Date:  1991-10-01       Impact factor: 3.857
  1 in total

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