Yansong Zheng1, Guilan Zhang2, Zhilai Chen1, Qiang Zeng3. 1. Health Management Institute, Beijing China. 2. Central Hospital of Xiaogan Health Examination, Tongji Medical College, Huazhong University of Science and Technology, Xiaogan, China. 3. Health Management Institute, Beijing China; Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing China.
Abstract
BACKGROUND: The association between age at menarche (AAM) and cardiovascular disease (CVD) has previously been investigated with controversial results. The relationship between the psychological characteristic of AAM and many cardiovascular risk factors remains unclear. PURPOSE: To assess the association between AAM and CVD risk factors in a large population. DESIGN AND SETTING: 13,242 women aged 24-79 years were recruited from China mainland during 2009-2013 for a cross-sectional, population-based study to investigate the association between AAM and CVD risk factors. Information on AAM was obtained from self-report and information on CVD risk factors from physical examination. RESULTS: In age-, body-mass-index- and height-adjusted analyses, AAM was positively associated with hypertension and 'college or above' educational level and incident CVD events. The adjusted odds ratios (ORs) and 95% confidence intervals for hypertension across AAM categories (≤12, 13-14, 15-16, and ≥17 years) were 0.820 (0.70-0.96), 0.82 (0.70-0.96), 0.88 (0.79-0.99) and 1 (referent), respectively; adjusted ORs for high educational level ('college or above') were 0.29 (0.24-0.34), 0.60 (0.41-0.51), 0.69 (0.62-0.76), and 1 (referent), respectively; adjusted ORs for incident CVD events were 0.18 (0.08-0.41), 0.18 (0.08-0.41), 0.62 (0.41-0.93), 1 (referent), respectively. CONCLUSIONS: Earlier AAM were positively associated with incident CVD events, hypertension and 'college or above' educational level.
BACKGROUND: The association between age at menarche (AAM) and cardiovascular disease (CVD) has previously been investigated with controversial results. The relationship between the psychological characteristic of AAM and many cardiovascular risk factors remains unclear. PURPOSE: To assess the association between AAM and CVD risk factors in a large population. DESIGN AND SETTING: 13,242 women aged 24-79 years were recruited from China mainland during 2009-2013 for a cross-sectional, population-based study to investigate the association between AAM and CVD risk factors. Information on AAM was obtained from self-report and information on CVD risk factors from physical examination. RESULTS: In age-, body-mass-index- and height-adjusted analyses, AAM was positively associated with hypertension and 'college or above' educational level and incident CVD events. The adjusted odds ratios (ORs) and 95% confidence intervals for hypertension across AAM categories (≤12, 13-14, 15-16, and ≥17 years) were 0.820 (0.70-0.96), 0.82 (0.70-0.96), 0.88 (0.79-0.99) and 1 (referent), respectively; adjusted ORs for high educational level ('college or above') were 0.29 (0.24-0.34), 0.60 (0.41-0.51), 0.69 (0.62-0.76), and 1 (referent), respectively; adjusted ORs for incident CVD events were 0.18 (0.08-0.41), 0.18 (0.08-0.41), 0.62 (0.41-0.93), 1 (referent), respectively. CONCLUSIONS: Earlier AAM were positively associated with incident CVD events, hypertension and 'college or above' educational level.
Entities:
Keywords:
Age at menarche; Cardiovascular disease; Large population; Risk factors
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