| Literature DB >> 27647368 |
Aws M Hamdy1, Zien Khaddour2, Najim A Al-Masoudi3, Qamar Rahman4, Christian Hering-Junghans2, Alexander Villinger2, Peter Langer5.
Abstract
Arylated coumarins were prepared by site-selective Suzuki-Miyaura cross-coupling reaction of the bis(triflate) of 4-methyl-6,7-dihydroxycoumarin. Triarylated coumarins were prepared by Suzuki-Miyaura cross-coupling reactions of 3-bromo-4-methyl-2-oxo-2H-chromene-6,7-diylbis(trifluoromethanesulfonate). The in vitro anti-HIV activity of the products was investigated. Two lead structures with considerable activities were identified.Entities:
Keywords: Anti-HIV activity; Coumarins; Regioselective synthesis; Suzuki–Miyaura cross-coupling reaction
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Year: 2016 PMID： 27647368 DOI： 10.1016/j.bmc.2016.08.029
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641