Literature DB >> 27646878

Immunopathology alters Th17 cell glucocorticoid sensitivity.

J Banuelos1, Y Cao1, S C Shin1, N Z Lu1.   

Abstract

Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17-related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  Th17 cells; asthma; autoimmunity; glucocorticoid resistance; glucocorticoids

Mesh：

Substances：

Year:  2016        PMID： 27646878      PMCID： PMC5315659          DOI： 10.1111/all.13051

Source DB:  PubMed          Journal:  Allergy        ISSN： 0105-4538            Impact factor:   13.146


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