Andrea R Zammit1, Ali Ezzati2, Molly E Zimmerman3, Richard B Lipton4, Michael L Lipton5, Mindy J Katz6. 1. Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: Andrea.Zammit@einstein.yu.edu. 2. Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Neurology, Montefiore Medical Center, Bronx, NY 10467, USA. 3. Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Psychology, Fordham University, Bronx, NY 10458, USA. 4. Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Neurology, Montefiore Medical Center, Bronx, NY 10467, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA. 5. The Gruss Magnetic Resonance Research Center and Departments of Radiology, Psychiatry and Behavioral Sciences and the Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Radiology, Montefiore Medical Center, Bronx, NY 10467, USA. 6. Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Abstract
INTRODUCTION: Selective hippocampal (HC) subfield atrophy has been reported in older adults with mild cognitive impairment and Alzheimer's disease. The goal of this study was to investigate the associations between the volume of hippocampal subfields and visual and verbal episodic memory in cognitively normal older adults. METHODS: This study was conducted on a subset of 133 participants from the Einstein Aging Study (EAS), a community-based study of non-demented older adults systematically recruited from the Bronx, N.Y. All participants completed comprehensive EAS neuropsychological assessment. Visual episodic memory was assessed using the Complex Figure Delayed Recall subtest from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Verbal episodic memory was assessed using Delayed Recall from the Free and Cued Selective Reminding Test (FCSRT). All participants underwent 3T MRI brain scanning with subsequent automatic measurement of the hemispheric hippocampal subfield volumes (CA1, CA2-CA3, CA4-dente gyrus, presubiculum, and subiculum). We used linear regressions to model the association between hippocampal subfield volumes and visual and verbal episodic memory tests while adjusting for age, sex, education, and total intracranial volume. RESULTS: Participants had a mean age of 78.9 (SD=5.1) and 60.2% were female. Total hippocampal volume was associated with Complex Figure Delayed Recall (β=0.31, p=0.001) and FCSRT Delayed Recall (β=0.27, p=0.007); subiculum volume was associated with Complex Figure Delayed Recall (β=0.27, p=0.002) and FCSRT Delayed Recall (β=0.24, p=0.010); CA1 was associated with Complex Figure Delayed Recall (β=0.26, p<0.002) and FCSRT Delayed Recall (β=0.20, p=0.025). CONCLUSIONS: Our findings confirm previous research on the specific roles of CA1 and subiculum in episodic memory. Our results suggest that hippocampal subfields have sensitive roles in the process of visual and verbal episodic memory.
INTRODUCTION: Selective hippocampal (HC) subfield atrophy has been reported in older adults with mild cognitive impairment and Alzheimer's disease. The goal of this study was to investigate the associations between the volume of hippocampal subfields and visual and verbal episodic memory in cognitively normal older adults. METHODS: This study was conducted on a subset of 133 participants from the Einstein Aging Study (EAS), a community-based study of non-demented older adults systematically recruited from the Bronx, N.Y. All participants completed comprehensive EAS neuropsychological assessment. Visual episodic memory was assessed using the Complex Figure Delayed Recall subtest from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Verbal episodic memory was assessed using Delayed Recall from the Free and Cued Selective Reminding Test (FCSRT). All participants underwent 3T MRI brain scanning with subsequent automatic measurement of the hemispheric hippocampal subfield volumes (CA1, CA2-CA3, CA4-dente gyrus, presubiculum, and subiculum). We used linear regressions to model the association between hippocampal subfield volumes and visual and verbal episodic memory tests while adjusting for age, sex, education, and total intracranial volume. RESULTS:Participants had a mean age of 78.9 (SD=5.1) and 60.2% were female. Total hippocampal volume was associated with Complex Figure Delayed Recall (β=0.31, p=0.001) and FCSRT Delayed Recall (β=0.27, p=0.007); subiculum volume was associated with Complex Figure Delayed Recall (β=0.27, p=0.002) and FCSRT Delayed Recall (β=0.24, p=0.010); CA1 was associated with Complex Figure Delayed Recall (β=0.26, p<0.002) and FCSRT Delayed Recall (β=0.20, p=0.025). CONCLUSIONS: Our findings confirm previous research on the specific roles of CA1 and subiculum in episodic memory. Our results suggest that hippocampal subfields have sensitive roles in the process of visual and verbal episodic memory.
Authors: Bruce Fischl; David H Salat; Evelina Busa; Marilyn Albert; Megan Dieterich; Christian Haselgrove; Andre van der Kouwe; Ron Killiany; David Kennedy; Shuna Klaveness; Albert Montillo; Nikos Makris; Bruce Rosen; Anders M Dale Journal: Neuron Date: 2002-01-31 Impact factor: 17.173
Authors: Laura L Eldridge; Stephen A Engel; Michael M Zeineh; Susan Y Bookheimer; Barbara J Knowlton Journal: J Neurosci Date: 2005-03-30 Impact factor: 6.167
Authors: Randy L Buckner; Denise Head; Jamie Parker; Anthony F Fotenos; Daniel Marcus; John C Morris; Abraham Z Snyder Journal: Neuroimage Date: 2004-10 Impact factor: 6.556
Authors: Ramy Ayoub; Rebecca M Ruddy; Elizabeth Cox; Adeoye Oyefiade; Daniel Derkach; Suzanne Laughlin; Benjamin Ades-Aron; Zahra Shirzadi; Els Fieremans; Bradley J MacIntosh; Cynthia B de Medeiros; Jovanka Skocic; Eric Bouffet; Freda D Miller; Cindi M Morshead; Donald J Mabbott Journal: Nat Med Date: 2020-07-27 Impact factor: 53.440
Authors: Javier Oltra-Cucarella; Miriam Sánchez-SanSegundo; Darren M Lipnicki; John D Crawford; Richard B Lipton; Mindy J Katz; Andrea R Zammit; Nikolaos Scarmeas; Efthimios Dardiotis; Mary H Kosmidis; Antonio Guaita; Roberta Vaccaro; Ki Woong Kim; Ji Won Han; Nicole A Kochan; Henry Brodaty; José A Pérez-Vicente; Luis Cabello-Rodríguez; Perminder S Sachdev; Rosario Ferrer-Cascales Journal: Int Psychogeriatr Date: 2018-10-25 Impact factor: 3.878
Authors: Diana Younan; Andrew J Petkus; Keith F Widaman; Xinhui Wang; Ramon Casanova; Mark A Espeland; Margaret Gatz; Victor W Henderson; JoAnn E Manson; Stephen R Rapp; Bonnie C Sachs; Marc L Serre; Sarah A Gaussoin; Ryan Barnard; Santiago Saldana; William Vizuete; Daniel P Beavers; Joel A Salinas; Helena C Chui; Susan M Resnick; Sally A Shumaker; Jiu-Chiuan Chen Journal: Brain Date: 2020-01-01 Impact factor: 13.501
Authors: Peyton L Delgorio; Lucy V Hiscox; Ana M Daugherty; Faria Sanjana; Ryan T Pohlig; James M Ellison; Christopher R Martens; Hillary Schwarb; Matthew D J McGarry; Curtis L Johnson Journal: Cereb Cortex Date: 2021-05-10 Impact factor: 5.357
Authors: Mario Amore Cecchini; Mônica Sanches Yassuda; Valéria Santoro Bahia; Leonardo Cruz de Souza; Henrique Cerqueira Guimarães; Paulo Caramelli; Maria Teresa Carthery-Goulart; Flávia Patrocínio; Maria Paula Foss; Vitor Tumas; Thaís Bento Lima-Silva; Sônia Maria Dozzi Brucki; Ricardo Nitrini; Sergio Della Sala; Mario A Parra Journal: J Neurol Date: 2017-09-11 Impact factor: 4.849
Authors: David G Coughlin; Jeffrey S Phillips; Emily Roll; Claire Peterson; Rebecca Lobrovich; Katya Rascovsky; Molly Ungrady; David A Wolk; Sandhitsu Das; Daniel Weintraub; Edward B Lee; John Q Trojanowski; Leslie M Shaw; Sanjeev Vaishnavi; Andrew Siderowf; Ilya M Nasrallah; David J Irwin; Corey T McMillan Journal: Neurobiol Aging Date: 2020-08-21 Impact factor: 4.673