| Literature DB >> 27645994 |
Vadim N Gladyshev1,2, Elias S Arnér3, Marla J Berry4, Regina Brigelius-Flohé5, Elspeth A Bruford6, Raymond F Burk7, Bradley A Carlson8, Sergi Castellano9, Laurent Chavatte10, Marcus Conrad11, Paul R Copeland12, Alan M Diamond13, Donna M Driscoll14, Ana Ferreiro15,16, Leopold Flohé17,18, Fiona R Green19, Roderic Guigó20,21, Diane E Handy22, Dolph L Hatfield8, John Hesketh23,24,25, Peter R Hoffmann4, Arne Holmgren3, Robert J Hondal26, Michael T Howard27, Kaixun Huang28, Hwa-Young Kim29, Ick Young Kim30, Josef Köhrle31, Alain Krol32, Gregory V Kryukov33, Byeong Jae Lee34, Byung Cheon Lee30, Xin Gen Lei35, Qiong Liu36, Alain Lescure32,37, Alexei V Lobanov38, Joseph Loscalzo39, Matilde Maiorino18, Marco Mariotti38, K Sandeep Prabhu40, Margaret P Rayman41, Sharon Rozovsky42, Gustavo Salinas43, Edward E Schmidt44, Lutz Schomburg31, Ulrich Schweizer45, Miljan Simonović46, Roger A Sunde47, Petra A Tsuji48, Susan Tweedie6, Fulvio Ursini18, Philip D Whanger49, Yan Zhang36.
Abstract
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein-encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP), SELENOT (selenoprotein T, SELT), SELENOV (selenoprotein V, SELV), and SELENOW (selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.Entities:
Keywords: function; gene name; genomics; nomenclature; selenium; selenocysteine; selenoprotein; structure-function
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Year: 2016 PMID： 27645994 PMCID： PMC5104929 DOI： 10.1074/jbc.M116.756155
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157