Literature DB >> 27645363

Utilization of PET imaging in differential diagnostics between a tumefactive multiple sclerosis lesion and low-grade glioma.

Aleksi Tarkkonen1, Eero Rissanen2, Terhi Tuokkola3, Laura Airas2.   

Abstract

We present a case where a 30-year-old man with a history of combined MS and Charcot-Marie-Tooth (CMT I) disease was additionally diagnosed and treated for grade II glioma (astrocytoma). Tumefactive MS and gliomas are sometimes difficult to distinguish from one another based on conventional magnetic resonance imaging (MRI). In our case, positron emission tomography (PET) scans with(11)C-methionine ((11)C-MET) and (11)C-PK11195 radioligands were performed to aid in differential diagnostics. The diagnosis was confirmed finally by brain biopsy. The usefulness of PET imaging in differential diagnostics between tumefactive MS and glioma is discussed.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Glioma; Multiple sclerosis; PET; TSPO

Mesh：

Year:  2016        PMID： 27645363     DOI： 10.1016/j.msard.2016.07.016

Source DB:  PubMed          Journal:  Mult Scler Relat Disord        ISSN： 2211-0348            Impact factor:   4.339


  5 in total

1.  TSPO PET for glioma imaging using the novel ligand 18F-GE-180: first results in patients with glioblastoma.

Authors:  Nathalie L Albert; M Unterrainer; D F Fleischmann; S Lindner; F Vettermann; A Brunegraf; L Vomacka; M Brendel; V Wenter; C Wetzel; R Rupprecht; J-C Tonn; C Belka; P Bartenstein; M Niyazi
Journal:  Eur J Nucl Med Mol Imaging       Date:  2017-08-19       Impact factor: 9.236

Review 2.  Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases.

Authors:  Anne-Claire Dupont; Bérenger Largeau; Maria Joao Santiago Ribeiro; Denis Guilloteau; Claire Tronel; Nicolas Arlicot
Journal:  Int J Mol Sci       Date:  2017-04-07       Impact factor: 5.923

3.  Imaging of translocator protein upregulation is selective for pro-inflammatory polarized astrocytes and microglia.

Authors:  Maria Pannell; Vasiliki Economopoulos; Thomas C Wilson; Veerle Kersemans; Patrick G Isenegger; James R Larkin; Sean Smart; Stuart Gilchrist; Véronique Gouverneur; Nicola R Sibson
Journal:  Glia       Date:  2019-09-03       Impact factor: 7.452

Review 4.  Evaluation of Microglial Activation in Multiple Sclerosis Patients Using Positron Emission Tomography.

Authors:  Laura Airas; Marjo Nylund; Eero Rissanen
Journal:  Front Neurol       Date:  2018-03-26       Impact factor: 4.003

Review 5.  Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers.

Authors:  Matteo Bauckneht; Selene Capitanio; Stefano Raffa; Luca Roccatagliata; Matteo Pardini; Caterina Lapucci; Cecilia Marini; Gianmario Sambuceti; Matilde Inglese; Paolo Gallo; Diego Cecchin; Flavio Nobili; Silvia Morbelli
Journal:  EJNMMI Radiopharm Chem       Date:  2019-04-08
  5 in total

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