Literature DB >> 27644988

Aberrant ketolysis fuels hepatocellular cancer progression.

Lorenzo Galluzzi1,2,3,4,5,6, Guido Kroemer2,3,4,5,7,8,9.   

Abstract

At odds with their normal counterparts, hepatocellular carcinoma cells efficiently utilize ketone bodies to proliferate despite serum deprivation. These findings, which have been recently published in Cell Research, identify a novel metabolic circuitry through which tumors successfully cope with adverse microenvironmental conditions.

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Year:  2016        PMID： 27644988      PMCID： PMC5113305          DOI： 10.1038/cr.2016.110

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

Review 1.  Organelle-Specific Initiation of Autophagy.

Authors:  Valentina Sica; Lorenzo Galluzzi; José Manuel Bravo-San Pedro; Valentina Izzo; Maria Chiara Maiuri; Guido Kroemer
Journal:  Mol Cell       Date:  2015-08-20       Impact factor: 17.970

Review 2.  Acetyl coenzyme A: a central metabolite and second messenger.

Authors:  Federico Pietrocola; Lorenzo Galluzzi; José Manuel Bravo-San Pedro; Frank Madeo; Guido Kroemer
Journal:  Cell Metab       Date:  2015-06-02       Impact factor: 27.287

Review 3.  Metabolic targets for cancer therapy.

Authors:  Lorenzo Galluzzi; Oliver Kepp; Matthew G Vander Heiden; Guido Kroemer
Journal:  Nat Rev Drug Discov       Date:  2013-10-11       Impact factor: 84.694

Review 4.  Making new contacts: the mTOR network in metabolism and signalling crosstalk.

Authors:  Mitsugu Shimobayashi; Michael N Hall
Journal:  Nat Rev Mol Cell Biol       Date:  2014-03       Impact factor: 94.444

Review 5.  AMPK: a nutrient and energy sensor that maintains energy homeostasis.

Authors:  D Grahame Hardie; Fiona A Ross; Simon A Hawley
Journal:  Nat Rev Mol Cell Biol       Date:  2012-03-22       Impact factor: 94.444

Review 6.  Hepatocellular carcinoma.

Authors:  Josep M Llovet; Jessica Zucman-Rossi; Eli Pikarsky; Bruno Sangro; Myron Schwartz; Morris Sherman; Gregory Gores
Journal:  Nat Rev Dis Primers       Date:  2016-04-14       Impact factor: 52.329

7.  Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.

Authors:  Tingting Li; Lin Wang; Long Zhang; Ronghui Yan; Kui Li; Songge Xing; Gongwei Wu; Lan Hu; Weidong Jia; Sheng-Cai Lin; Chi V Dang; Libing Song; Ping Gao; Huafeng Zhang
Journal:  Cell Res       Date:  2016-09-20       Impact factor: 25.617

Review 8.  Autophagy in malignant transformation and cancer progression.

Authors:  Lorenzo Galluzzi; Federico Pietrocola; José Manuel Bravo-San Pedro; Ravi K Amaravadi; Eric H Baehrecke; Francesco Cecconi; Patrice Codogno; Jayanta Debnath; David A Gewirtz; Vassiliki Karantza; Alec Kimmelman; Sharad Kumar; Beth Levine; Maria Chiara Maiuri; Seamus J Martin; Josef Penninger; Mauro Piacentini; David C Rubinsztein; Hans-Uwe Simon; Anne Simonsen; Andrew M Thorburn; Guillermo Velasco; Kevin M Ryan; Guido Kroemer
Journal:  EMBO J       Date:  2015-02-23       Impact factor: 11.598

9.  HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

Authors:  Tingting Li; Xinghua Li; Long Zhang; Linchong Sun; Xiaoping He; Xiuying Zhong; Dongya Jia; Libing Song; Gregg L Semenza; Ping Gao; Huafeng Zhang
Journal:  Cell Rep       Date:  2014-09-18       Impact factor: 9.423

Review 10.  Hallmarks of cancer: the next generation.

Authors:  Douglas Hanahan; Robert A Weinberg
Journal:  Cell       Date:  2011-03-04       Impact factor: 41.582
  10 in total
  2 in total

1.  Broad spectrum proteomics analysis of the inferior colliculus following acute hydrogen sulfide exposure.

Authors:  Dong-Suk Kim; Poojya Anantharam; Andrea Hoffmann; Mitchell L Meade; Nadja Grobe; Jeffery M Gearhart; Elizabeth M Whitley; Belinda Mahama; Wilson K Rumbeiha
Journal:  Toxicol Appl Pharmacol       Date:  2018-06-19       Impact factor: 4.219

Review 2.  Important Functions and Molecular Mechanisms of Mitochondrial Redox Signaling in Pulmonary Hypertension.

Authors:  Jorge Reyes-García; Abril Carbajal-García; Annarita Di Mise; Yun-Min Zheng; Xiangdong Wang; Yong-Xiao Wang
Journal:  Antioxidants (Basel)       Date:  2022-02-28
  2 in total

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