| Literature DB >> 27644937 |
Anand A Joshi1, Soniya S Vaidya1,2, Marie V St-Pierre3, Andrei M Mikheev4,5, Kelly E Desino6,7, Abner N Nyandege1, Kenneth L Audus6, Jashvant D Unadkat4, Phillip M Gerk8.
Abstract
The human placenta fulfills a variety of essential functions during prenatal life. Several ABC transporters are expressed in the human placenta, where they play a role in the transport of endogenous compounds and may protect the fetus from exogenous compounds such as therapeutic agents, drugs of abuse, and other xenobiotics. To date, considerable progress has been made toward understanding ABC transporters in the placenta. Recent studies on the expression and functional activities are discussed. This review discusses the placental expression and functional roles of several members of ABC transporter subfamilies B, C, and G including MDR1/P-glycoprotein, the MRPs, and BCRP, respectively. Since placental ABC transporters modulate fetal exposure to various compounds, an understanding of their functional and regulatory mechanisms will lead to more optimal medication use when necessary in pregnancy.Entities:
Keywords: P-glycoprotein; breast cancer resistance protein; drug transport; multidrug resistance-associated protein; placenta; regulation of expression
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Year: 2016 PMID： 27644937 PMCID： PMC5384842 DOI： 10.1007/s11095-016-2028-8
Source DB: PubMed Journal: Pharm Res ISSN： 0724-8741 Impact factor: 4.200