Alexander Arthur1,2, Phillip J McCall1,2, Lisa Jolly3, John Kinsella1, Alan Kirk4, Ben G Shelley1,2. 1. Academic Unit of Anesthesia, Pain & Critical Care Medicine, University of Glasgow, Glasgow, UK. 2. Department of Anesthesia, Golden Jubilee National Hospital, Clydebank, UK. 3. Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK. 4. Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Clydebank, UK.
Abstract
AIM: We investigated if the serum biomarkers of endothelial glycocalyx layer (EGL) disruption, heparan sulfate proteoglycan (HSPG) and syndecan-1 (SDC1) were elevated following lung resection surgery. METHODS: Plasma samples were collected from 16 patients undergoing lobectomy for primary lung cancer. HSPG and SDC1 were measured at five perioperative timepoints. Postoperative oxygenation was recorded. RESULTS: Post-hoc pair wise comparisons showed SDC1 concentration was significantly elevated on postoperative day 2, p < 0.001. There was no relationship found between HSPG or SDC1 levels and postoperative oxygenation. CONCLUSION: Our pilot study is the first to provide evidence of EGL disruption following lung resection surgery. We hypothesize that EGL disruption is involved in the pathogenesis of post-lung resection acute lung injury. Abstract presentation: This work was presented in a part at the Anaesthetic Research Society Spring Meeting, Royal College of Anaesthetists, London, UK, 22 April 2015.
AIM: We investigated if the serum biomarkers of endothelial glycocalyx layer (EGL) disruption, heparan sulfate proteoglycan (HSPG) and syndecan-1 (SDC1) were elevated following lung resection surgery. METHODS: Plasma samples were collected from 16 patients undergoing lobectomy for primary lung cancer. HSPG and SDC1 were measured at five perioperative timepoints. Postoperative oxygenation was recorded. RESULTS: Post-hoc pair wise comparisons showed SDC1 concentration was significantly elevated on postoperative day 2, p < 0.001. There was no relationship found between HSPG or SDC1 levels and postoperative oxygenation. CONCLUSION: Our pilot study is the first to provide evidence of EGL disruption following lung resection surgery. We hypothesize that EGL disruption is involved in the pathogenesis of post-lung resection acute lung injury. Abstract presentation: This work was presented in a part at the Anaesthetic Research Society Spring Meeting, Royal College of Anaesthetists, London, UK, 22 April 2015.
Authors: Hendrik Drinhaus; Daniel C Schroeder; Nicolas Hunzelmann; Holger Herff; Thorsten Annecke; Bernd W Böttiger; Wolfgang A Wetsch Journal: J Clin Med Date: 2022-09-30 Impact factor: 4.964