| Literature DB >> 27642654 |
Miguel Gomez-Mendoza1,2, Akos Banyasz3, Thierry Douki1,2, Dimitra Markovitsi3, Jean-Luc Ravanat1,2.
Abstract
It has been shown that in addition to formation of pyrimidine dimers, UV irradiation of DNA in the absence of photosensitizer also induces formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine, but the mechanism of formation of that oxidized base has not been clearly established. In the present study, we provide an unambiguous demonstration that absorption of UVC and UVB radiation by the nucleobases induces DNA oxidation via a direct process (one-electron oxidation) and not singlet oxygen. Evidence arose from the fact that polyamine-guanine adducts that are specifically produced through the transient formation of guanine radical cation are generated following UV irradiation of DNA in the presence of a polyamine even in the absence of any photosensitizer.Entities:
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Year: 2016 PMID： 27642654 DOI： 10.1021/acs.jpclett.6b01781
Source DB: PubMed Journal: J Phys Chem Lett ISSN： 1948-7185 Impact factor: 6.475