SatyaVati Rana1, Rajesh Kumar Morya2, Aastha Malik3, Sanjay Kumar Bhadada4, Naresh Sachdeva5, Gaurav Sharma6. 1. Department of Gastroenterology, Post Graduate Institute of Medical Research and Education, Chandigarh 160012, India. Electronic address: svrana25@hotmail.com. 2. Department of Gastroenterology, Post Graduate Institute of Medical Research and Education, Chandigarh 160012, India. Electronic address: rajeshmorya1987@gmail.com. 3. Department of Gastroenterology, Post Graduate Institute of Medical Research and Education, Chandigarh 160012, India. Electronic address: malikaastha@gmail.com. 4. Department of Endocrinology, Post Graduate Institute of Medical Research and Education, Chandigarh 160012, India. Electronic address: bhadadask@rediffmail.com. 5. Department of Endocrinology, Post Graduate Institute of Medical Research and Education, Chandigarh 160012, India. Electronic address: naresh_sach@rediffmail.com. 6. Department of Gastroenterology, Post Graduate Institute of Medical Research and Education, Chandigarh 160012, India. Electronic address: gauravsharma1285@gmail.com.
Abstract
BACKGROUND: Type 2 diabetes mellitus is chronic metabolic disorder. Common gastrointestinal symptoms in type 2 diabetic patients are flatulence, constipation and/or diarrhea. Reason for these may be lactose intolerance leading to change in vitamin D, Calcium and parathyroid hormone which further regulate bone mineralization. AIM: To measure lactose intolerance, vitamin D, calcium and parathyroid hormone in type 2 diabetic patients. MATERIAL AND METHODS: 150 type 2 diabetic patients attending Endocrinology Clinic in PGI, Chandigarh and 150 age and sex matched healthy controls were enrolled. Lactose intolerance was measured using non-invasive lactose breath test. 25-hydroxyvitamin D (total) and Parathyroid hormone were measured in plasma using immunoassay. Serum calcium was measured using auto analyzer. T score was recorded from DXA scan for bone mineral density measurement. RESULTS: Lactose intolerance was observed significantly higher (p<0.001) diabetic patients (59.3%) as compared to controls (42%). Levels of plasma 25-OH vitamin D (total), parathyroid hormone and serum calcium were significantly lower in patients as compared to controls. Furthermore, levels of plasma 25-OH vitamin D (total), parathyroid hormone and serum calcium were more decreased in lactose intolerant diabetic patients than lactose tolerant patients. Sixty seven percent (67%) of diabetic patients suffered from osteoporosis and 20% of controls. Eighty percent (80%) diabetic patients and 16% controls with osteoporosis suffered from lactose intolerance. CONCLUSION: From this study we can conclude that measurement of lactose intolerance using non-invasive lactose breath test is suggested for type 2 diabetic patients along with timely measurement of 25-OH vitamin D (total), calcium and parathyroid hormone levels.
BACKGROUND: Type 2 diabetes mellitus is chronic metabolic disorder. Common gastrointestinal symptoms in type 2 diabeticpatients are flatulence, constipation and/or diarrhea. Reason for these may be lactose intolerance leading to change in vitamin D, Calcium and parathyroid hormone which further regulate bone mineralization. AIM: To measure lactose intolerance, vitamin D, calcium and parathyroid hormone in type 2 diabeticpatients. MATERIAL AND METHODS: 150 type 2 diabeticpatients attending Endocrinology Clinic in PGI, Chandigarh and 150 age and sex matched healthy controls were enrolled. Lactose intolerance was measured using non-invasive lactose breath test. 25-hydroxyvitamin D (total) and Parathyroid hormone were measured in plasma using immunoassay. Serum calcium was measured using auto analyzer. T score was recorded from DXA scan for bone mineral density measurement. RESULTS:Lactose intolerance was observed significantly higher (p<0.001) diabeticpatients (59.3%) as compared to controls (42%). Levels of plasma 25-OH vitamin D (total), parathyroid hormone and serum calcium were significantly lower in patients as compared to controls. Furthermore, levels of plasma 25-OH vitamin D (total), parathyroid hormone and serum calcium were more decreased in lactose intolerant diabeticpatients than lactose tolerant patients. Sixty seven percent (67%) of diabeticpatients suffered from osteoporosis and 20% of controls. Eighty percent (80%) diabeticpatients and 16% controls with osteoporosis suffered from lactose intolerance. CONCLUSION: From this study we can conclude that measurement of lactose intolerance using non-invasive lactose breath test is suggested for type 2 diabeticpatients along with timely measurement of 25-OH vitamin D (total), calcium and parathyroid hormone levels.
Authors: Adam D Farmer; Anne Grave Pedersen; Birgitte Brock; Poul Erik Jakobsen; Jesper Karmisholt; Sahar D Mohammed; S Mark Scott; Asbjørn Mohr Drewes; Christina Brock Journal: Diabetologia Date: 2017-01-20 Impact factor: 10.122