Inna Lobeck1, Phylicia Dupree1, Rebekah Karns2, David Rodeberg3, Daniel von Allmen1, Roshni Dasgupta4. 1. Division of General and Thoracic Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. 2. Division of Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. 3. Division of Pediatric Surgery, East Carolina University, Greenville, NC, USA. 4. Division of General and Thoracic Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Roshni.Dasgupta@cchmc.org.
Abstract
BACKGROUND: Lymph node sampling is integral in the management of extremity and paratesticular rhabdomyosarcoma (RMS). The aim of this study was to determine overall surgical compliance with treatment protocols and impact of nodal sampling outcomes in these tumors. METHODS: A query of the surveillance, epidemiology, and end results program (SEER) database was performed from 2003 to 2008 for patients <19years of age with RMS. Data obtained included demographics, five-year survival and rate of nodal sampling. Analysis was performed utilizing chi-squared, Kaplan-Meier and hazard ratio modeling. RESULTS: Of 537 patients with extremity RMS, nodal sampling was performed in 25.7% (n=138). This lack of nodal sampling had a negative outcome on survival (p=0.004). Sixty five patients with paratesticular RMS aged greater than 10 were identified and also displayed low rates of lymph node sampling (47.7%, n=31). For paratesticular patients, a similar increase in survival was seen in patients who underwent nodal evaluation (p=0.024). CONCLUSION: Lymph node sampling is the standard of care in RMS. However, surgical compliance with treatment protocols is poor. Nodal evaluation correlated significantly with overall survival. These findings suggest a need for improved education among surgeons and oncologists regarding the need lymph node assessment in pediatric oncology patients. Evidence rating/classification: Prognosis study, Level III.
BACKGROUND: Lymph node sampling is integral in the management of extremity and paratesticular rhabdomyosarcoma (RMS). The aim of this study was to determine overall surgical compliance with treatment protocols and impact of nodal sampling outcomes in these tumors. METHODS: A query of the surveillance, epidemiology, and end results program (SEER) database was performed from 2003 to 2008 for patients <19years of age with RMS. Data obtained included demographics, five-year survival and rate of nodal sampling. Analysis was performed utilizing chi-squared, Kaplan-Meier and hazard ratio modeling. RESULTS: Of 537 patients with extremity RMS, nodal sampling was performed in 25.7% (n=138). This lack of nodal sampling had a negative outcome on survival (p=0.004). Sixty five patients with paratesticular RMS aged greater than 10 were identified and also displayed low rates of lymph node sampling (47.7%, n=31). For paratesticular patients, a similar increase in survival was seen in patients who underwent nodal evaluation (p=0.024). CONCLUSION: Lymph node sampling is the standard of care in RMS. However, surgical compliance with treatment protocols is poor. Nodal evaluation correlated significantly with overall survival. These findings suggest a need for improved education among surgeons and oncologists regarding the need lymph node assessment in pediatric oncology patients. Evidence rating/classification: Prognosis study, Level III.
Authors: Timothy N Rogers; Guido Seitz; Jörg Fuchs; Helene Martelli; Roshni Dasgupta; Jonathan C Routh; Douglas S Hawkins; Ewa Koscielniak; Gianni Bisogno; David A Rodeberg Journal: Pediatr Blood Cancer Date: 2021-02-01 Impact factor: 3.838
Authors: Jonathan C Routh; Roshni Dasgupta; Yueh-Yun Chi; Margarett Shnorhavorian; Jing Tian; David O Walterhouse; John Breneman; Suzanne L Wolden; Carola A Arndt; Douglas S Hawkins; David A Rodeberg Journal: Int J Cancer Date: 2020-07-11 Impact factor: 7.396
Authors: Sheila E J Terwisscha van Scheltinga; Marc H W A Wijnen; Hélène Martelli; Timothy Rogers; Henry Mandeville; Mark N Gaze; Keiran McHugh; Nadege Corradini; Daniel Orbach; Meriel Jenney; Anna Kelsey; Julia Chisholm; Soledad Gallego; Heidi Glosli; Andrea Ferrari; Ilaria Zanetti; Gian Luca De Salvo; Veronique Minard-Colin; Giani Bisogno; Max M van Noesel; Hans H M Merks Journal: Cancer Med Date: 2020-09-01 Impact factor: 4.452
Authors: Roelof van Ewijk; Reineke A Schoot; Monika Sparber-Sauer; Simone A J Ter Horst; Nina Jehanno; Lise Borgwardt; Bart de Keizer; Johannes H M Merks; Alberto de Luca; Kieran McHugh; Thekla von Kalle; Jürgen F Schäfer; Rick R van Rijn Journal: Pediatr Radiol Date: 2021-06-17