Jens Christian Rehammar1, Jens Brock Johansen2, Maj-Britt Jensen3, Lars Videbæk4, Ole Dan Jørgensen5, Ebbe Lorenzen6, Marianne Ewertz6. 1. Department of Oncology, Odense University Hospital, Denmark; Institute of Clinical Research, University of Southern Denmark, Denmark. Electronic address: christian@rehammar.se. 2. Department of Cardiology, Odense University Hospital, Denmark; Danish Pacemaker and ICR Registry Secretariat, Denmark. 3. Danish Breast Cancer Cooperative Group Secretariat, Copenhagen University Hospital, Rigshospitalet, Denmark. 4. Department of Cardiology, Odense University Hospital, Denmark. 5. Danish Pacemaker and ICR Registry Secretariat, Denmark; Department of Thoracic Surgery, Odense University Hospital, Denmark. 6. Department of Oncology, Odense University Hospital, Denmark; Institute of Clinical Research, University of Southern Denmark, Denmark.
Abstract
BACKGROUND AND PURPOSE: To examine the risk of cardiac conduction abnormalities or severe ventricular arrhythmias requiring implantation of a cardiac implantable electronic device (CIED), either a pacemaker or an implantable cardioverter-defibrillator, subsequent to breast cancer (BC) radiotherapy (RT). MATERIAL AND METHODS: All women treated for early-stage BC in Denmark from 1982 to 2005 were identified from the Danish Breast Cancer Cooperative Group. By record linkage to the Danish Pacemaker and ICD Registry information was retrieved on CIED implants subsequent to RT. Standardized incidence ratios (SIR) of CIED implantation were estimated for women receiving RT and compared to women not receiving RT for BC. Uni- and multivariate Poisson regression models were used to estimate incidence rate ratios (IRR) among irradiated women compared to non-irradiated. RESULTS: Of 44,423 BC patients, 179 had a CIED implanted among 18,251 women who received RT, and 401 had a CIED in 26,172 who did not receive RT. The unadjusted IRR was 1.09 (0.91-1.30 95% CI) for CIED implants among women receiving RT compared to non-irradiated women and the IRR was 1.13 (0.93-1.38 95% CI) when adjustments were made. CONCLUSIONS: BC RT as practiced in Denmark in 1982-2005 did not increase the risk of CIED implants. This indicates that RT for BC does not increase the risk of severe ventricular arrhythmias or cardiac conduction abnormalities.
BACKGROUND AND PURPOSE: To examine the risk of cardiac conduction abnormalities or severe ventricular arrhythmias requiring implantation of a cardiac implantable electronic device (CIED), either a pacemaker or an implantable cardioverter-defibrillator, subsequent to breast cancer (BC) radiotherapy (RT). MATERIAL AND METHODS: All women treated for early-stage BC in Denmark from 1982 to 2005 were identified from the Danish Breast Cancer Cooperative Group. By record linkage to the Danish Pacemaker and ICD Registry information was retrieved on CIED implants subsequent to RT. Standardized incidence ratios (SIR) of CIED implantation were estimated for women receiving RT and compared to women not receiving RT for BC. Uni- and multivariate Poisson regression models were used to estimate incidence rate ratios (IRR) among irradiated women compared to non-irradiated. RESULTS: Of 44,423 BC patients, 179 had a CIED implanted among 18,251 women who received RT, and 401 had a CIED in 26,172 who did not receive RT. The unadjusted IRR was 1.09 (0.91-1.30 95% CI) for CIED implants among women receiving RT compared to non-irradiated women and the IRR was 1.13 (0.93-1.38 95% CI) when adjustments were made. CONCLUSIONS: BC RT as practiced in Denmark in 1982-2005 did not increase the risk of CIED implants. This indicates that RT for BC does not increase the risk of severe ventricular arrhythmias or cardiac conduction abnormalities.
Authors: Kyle Wang; Kevin A Pearlstein; Nicholas D Patchett; Allison M Deal; Panayiotis Mavroidis; Brian C Jensen; Matthew B Lipner; Timothy M Zagar; Yue Wang; Carrie B Lee; Michael J Eblan; Julian G Rosenman; Mark A Socinski; Thomas E Stinchcombe; Lawrence B Marks Journal: Radiother Oncol Date: 2017-10-16 Impact factor: 6.280
Authors: M Y Errahmani; J Thariat; J Ferrières; L Panh; M Locquet; M Lapeyre-Mestre; G Guernec; M O Bernier; S Boveda; S Jacob Journal: Int J Cardiol Heart Vasc Date: 2021-12-25