Shan Huang1, Dajin Zou2, Wenfang Peng3, Xiaohong Jiang3, Kan Shao3, Lili Xia3, Yubin Tang3. 1. Endocrinology Department, Changhai Hospital, Second Military Medical University, Changhai Road No. 174, 200433 Shanghai, PR China; Endocrinology Department, Shanghai Tongren hospital Affiliated to Shanghai Jiaotong University School of Medicine, 200336 Shanghai, PR China. 2. Endocrinology Department, Changhai Hospital, Second Military Medical University, Changhai Road No. 174, 200433 Shanghai, PR China. Electronic address: dajinzou_zd@163.com. 3. Endocrinology Department, Shanghai Tongren hospital Affiliated to Shanghai Jiaotong University School of Medicine, 200336 Shanghai, PR China.
Abstract
PURPOSE: To investigate the effects of asymmetric dimethyl-arginine (ADMA), adiponectin (APN) and apelin in predicting macroangiopathy in impaired glucose regulation (IGR) patients. METHODS: A total of 210 patients undergoing oral glucose tolerance test were included in this study. They were classified to normal glucose tolerance (NGT, n=42), impaired fasting glucose (IFG, n=36), impaired glucose tolerance (IGT, n=92, including 44 IGT1 and 48 IGT2 patients) and IFG+IGT (n=40) groups. APN, apelin and ADMA levels, blood pressure, blood lipid, insulin, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) were detected. The severity and extent of coronary atherosclerosis were determined by the Gensini score. RESULTS: The prevalence of coronary heart disease and Gensini scores in IGT and IFG+IGT groups were similar but both were higher than NGT and IFG groups (all P<0.05). Lower APN, higher ADMA and apelin levels were witnessed in IGT and IGT+IFG groups compared with NGT and IFG groups (all P<0.05). IGT2 group had higher 2-h PG and apelin levels and Gensini scores but lower APN levels than IGT1 group (all P<0.05). Gensini score was positively correlated with apelin (r=0.669) and ADMA (r=0.764), but were negatively correlated with APN (r=-0.555, all P<0.001). ADMA and APN were the independent factors affecting Gensini score. CONCLUSION: ADMA and APN levels could be predictive factors for macroangiopathy in IGR patients, especially in IGT cases. Copyright Â
PURPOSE: To investigate the effects of asymmetric dimethyl-arginine (ADMA), adiponectin (APN) and apelin in predicting macroangiopathy in impaired glucose regulation (IGR) patients. METHODS: A total of 210 patients undergoing oral glucose tolerance test were included in this study. They were classified to normal glucose tolerance (NGT, n=42), impaired fasting glucose (IFG, n=36), impaired glucose tolerance (IGT, n=92, including 44 IGT1 and 48 IGT2 patients) and IFG+IGT (n=40) groups. APN, apelin and ADMA levels, blood pressure, blood lipid, insulin, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) were detected. The severity and extent of coronary atherosclerosis were determined by the Gensini score. RESULTS: The prevalence of coronary heart disease and Gensini scores in IGT and IFG+IGT groups were similar but both were higher than NGT and IFG groups (all P<0.05). Lower APN, higher ADMA and apelin levels were witnessed in IGT and IGT+IFG groups compared with NGT and IFG groups (all P<0.05). IGT2 group had higher 2-h PG and apelin levels and Gensini scores but lower APN levels than IGT1 group (all P<0.05). Gensini score was positively correlated with apelin (r=0.669) and ADMA (r=0.764), but were negatively correlated with APN (r=-0.555, all P<0.001). ADMA and APN were the independent factors affecting Gensini score. CONCLUSION:ADMA and APN levels could be predictive factors for macroangiopathy in IGR patients, especially in IGT cases. Copyright Â