Suchitra Thunga1, Anusmitha Andrews2, John Ramapuram3, Kapaettu Satyamoorthy4, Hema Kini5, B Unnikrishnan6, Prabha Adhikari3, Prakhar Singh7, Shama Prasada Kabekkodu8, Samatha Bhat8, Anagha Kadam8, Avinash K Shetty9. 1. Department of OBG, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India. 2. Life Line Hospital, Pathanamthitta, Kerala, India. 3. Department of Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India. 4. Centre for Molecular and Cellular Biology, School of Life Sciences, Manipal University, Karnataka, India. 5. Department of Pathology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India. 6. Department of Community Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India. 7. Kasturba Medical College, Manipal University, Mangalore, Karnataka, India. 8. Department of Biotechnology, School of Life Sciences, Manipal University, Manipal, Karnataka, India. 9. Department of Pediatrics, Wake Forest School of Medicine, Salem, North Carolina, USA.
Abstract
AIM: The aim of this study was to examine the association between CD4 count, human papilloma virus (HPV) infection, and the risk of cervical intraepithelial neoplasia among HIV-infected women. METHODS: A cross-sectional study was conducted among 104 HIV-infected women attending an antiretroviral therapy clinic. They underwent Pap smear and cervical HPV DNA testing. RESULTS: The overall prevalence of HPV infection was 57.7%. HPV 16 was the commonest genotype found (38.5%); HPV 16 and 18 put together contributed to 73.3% of HPV infection; 27.5% of HIV-infected women had squamous cell abnormalities. Cervical intraepithelial neoplasia was less likely among women with CD4 count > 500/mm3 (12%) and in those without opportunistic infections (17.8%). The prevalence of high-risk HPV infection was higher in women with high-grade squamous intraepithelial lesions or greater lesions (85.7%) as compared to women with normal cytology (52.1%). CONCLUSION: The high prevalence of HPV infection and cervical intraepithelial neoplasia in HIV-infected women warrants the need for regular Pap smear screening in these women and routine HPV vaccination for adolescents to reduce the burden of cervical cancer in India.
AIM: The aim of this study was to examine the association between CD4 count, human papilloma virus (HPV) infection, and the risk of cervical intraepithelial neoplasia among HIV-infectedwomen. METHODS: A cross-sectional study was conducted among 104 HIV-infectedwomen attending an antiretroviral therapy clinic. They underwent Pap smear and cervical HPV DNA testing. RESULTS: The overall prevalence of HPV infection was 57.7%. HPV 16 was the commonest genotype found (38.5%); HPV 16 and 18 put together contributed to 73.3% of HPV infection; 27.5% of HIV-infectedwomen had squamous cell abnormalities. Cervical intraepithelial neoplasia was less likely among women with CD4 count > 500/mm3 (12%) and in those without opportunistic infections (17.8%). The prevalence of high-risk HPV infection was higher in women with high-grade squamous intraepithelial lesions or greater lesions (85.7%) as compared to women with normal cytology (52.1%). CONCLUSION: The high prevalence of HPV infection and cervical intraepithelial neoplasia in HIV-infectedwomen warrants the need for regular Pap smear screening in these women and routine HPV vaccination for adolescents to reduce the burden of cervical cancer in India.
Authors: Rhoda K Wanyenze; John Baptist Bwanika; Jolly Beyeza-Kashesya; Shaban Mugerwa; Jim Arinaitwe; Joseph K B Matovu; Violet Gwokyalya; Dickson Kasozi; Justine Bukenya; Fred Makumbi Journal: Glob Health Action Date: 2017 Impact factor: 2.640