Literature DB >> 27640169

Salivary Amylase: Digestion and Metabolic Syndrome.

Catherine Peyrot des Gachons1, Paul A S Breslin2,3.   

Abstract

Salivary amylase is a glucose-polymer cleavage enzyme that is produced by the salivary glands. It comprises a small portion of the total amylase excreted, which is mostly made by the pancreas. Amylases digest starch into smaller molecules, ultimately yielding maltose, which in turn is cleaved into two glucose molecules by maltase. Starch comprises a significant portion of the typical human diet for most nationalities. Given that salivary amylase is such a small portion of total amylase, it is unclear why it exists and whether it conveys an evolutionary advantage when ingesting starch. This review will consider the impact of salivary amylase on oral perception, nutrient signaling, anticipatory metabolic reflexes, blood sugar, and its clinical implications for preventing metabolic syndrome and obesity.

Entities:  

Keywords:  AMY1 copy number variation; Glucose homeostasis; Insulin; Metabolic syndrome; Salivary amylase; Starch digestion

Mesh：

Substances：

Year:  2016        PMID： 27640169      PMCID： PMC6825871          DOI： 10.1007/s11892-016-0794-7

Source DB:  PubMed          Journal:  Curr Diab Rep        ISSN： 1534-4827            Impact factor:   4.810


  77 in total

1.  Variation in gene copy number and polymorphism of the human salivary amylase isoenzyme system in Caucasians.

Authors:  R A Bank; E H Hettema; M A Muijs; G Pals; F Arwert; D I Boomsma; J C Pronk
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132

Review 2.  The endocrine secretion of mammalian digestive enzymes by exocrine glands.

Authors:  L Isenman; C Liebow; S Rothman
Journal:  Am J Physiol       Date:  1999-02

3.  Substrate differentiation of human pancreatic and salivary alpha-amylases.

Authors:  F F Hall; C R Ratliff; T Hayakawa; T W Culp; N C Hightower
Journal:  Am J Dig Dis       Date:  1970-11

4.  Evolution of the human alpha-amylase multigene family through unequal, homologous, and inter- and intrachromosomal crossovers.

Authors:  P C Groot; W H Mager; N V Henriquez; J C Pronk; F Arwert; R J Planta; A W Eriksson; R R Frants
Journal:  Genomics       Date:  1990-09       Impact factor: 5.736

5.  Amylase gene structures in primates: retroposon insertions and promoter evolution.

Authors:  L C Samuelson; R S Phillips; L J Swanberg
Journal:  Mol Biol Evol       Date:  1996-07       Impact factor: 16.240

6.  Salivary alpha-amylase as a measure of endogenous adrenergic activity.

Authors:  R T Chatterton; K M Vogelsong; Y C Lu; A B Ellman; G A Hudgens
Journal:  Clin Physiol       Date:  1996-07

7.  Obesity, starch digestion and amylase: association between copy number variants at human salivary (AMY1) and pancreatic (AMY2) amylase genes.

Authors:  Danielle Carpenter; Sugandha Dhar; Laura M Mitchell; Beiyuan Fu; Jess Tyson; Nzar A A Shwan; Fengtang Yang; Mark G Thomas; John A L Armour
Journal:  Hum Mol Genet       Date:  2015-03-18       Impact factor: 6.150

8.  Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity.

Authors:  Christina L Usher; Robert E Handsaker; Tõnu Esko; Marcus A Tuke; Michael N Weedon; Alex R Hastie; Han Cao; Jennifer E Moon; Seva Kashin; Christian Fuchsberger; Andres Metspalu; Carlos N Pato; Michele T Pato; Mark I McCarthy; Michael Boehnke; David M Altshuler; Timothy M Frayling; Joel N Hirschhorn; Steven A McCarroll
Journal:  Nat Genet       Date:  2015-06-22       Impact factor: 38.330

9.  T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.

Authors:  Robert F Margolskee; Jane Dyer; Zaza Kokrashvili; Kieron S H Salmon; Erwin Ilegems; Kristian Daly; Emeline L Maillet; Yuzo Ninomiya; Bedrich Mosinger; Soraya P Shirazi-Beechey
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-27       Impact factor: 11.205

10.  Amylase activity is associated with AMY2B copy numbers in dog: implications for dog domestication, diet and diabetes.

Authors:  Maja Arendt; Tove Fall; Kerstin Lindblad-Toh; Erik Axelsson
Journal:  Anim Genet       Date:  2014-06-28       Impact factor: 3.169
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  22 in total

1.  Starch Digestion-Related Amylase Genetic Variant Affects 2-Year Changes in Adiposity in Response to Weight-Loss Diets: The POUNDS Lost Trial.

Authors:  Yoriko Heianza; Dianjianyi Sun; Tiange Wang; Tao Huang; George A Bray; Frank M Sacks; Lu Qi
Journal:  Diabetes       Date:  2017-06-28       Impact factor: 9.461

2.  Increased oral processing and a slower eating rate increase glycaemic, insulin and satiety responses to a mixed meal tolerance test.

Authors:  Ai Ting Goh; Jie Ying Michelle Choy; Xin Hui Chua; Shalini Ponnalagu; Chin Meng Khoo; Clare Whitton; Rob Martinus van Dam; Ciarán Gerard Forde
Journal:  Eur J Nutr       Date:  2021-01-02       Impact factor: 5.614

3.  The Oral Bacterium Fusobacterium nucleatum Binds Staphylococcus aureus and Alters Expression of the Staphylococcal Accessory Regulator sarA.

Authors:  Bruno P Lima; Linda I Hu; Gerrit W Vreeman; Douglas B Weibel; Renate Lux
Journal:  Microb Ecol       Date:  2018-11-24       Impact factor: 4.552

4.  Drain Amylase Levels in the Early Diagnosis of Gastric Leak after Laparoscopic Sleeve Gastrectomy.

Authors:  Lucia Romano; Antonio Giuliani; Marino Di Furia; Danilo Meloni; Giovanni Cianca; Antonella Mattei; Fabiana Fiasca; Emilio Tonelli; Francesco Carlei; Mario Schietroma
Journal:  Med Princ Pract       Date:  2021-06-22       Impact factor: 1.927

Review 5.  Cephalic phase insulin release: A review of its mechanistic basis and variability in humans.

Authors:  Alexa J Pullicin; John I Glendinning; Juyun Lim
Journal:  Physiol Behav       Date:  2021-07-09

6.  Oxidative Biochemistry Disbalance and Changes on Proteomic Profile in Salivary Glands of Rats Induced by Chronic Exposure to Methylmercury.

Authors:  Leonardo Oliveira Bittencourt; Bruna Puty; Senda Charone; Walessa Alana Bragança Aragão; Paulo Mecenas Farias-Junior; Marcia Cristina Freitas Silva; Maria Elena Crespo-Lopez; Aline de Lima Leite; Marilia Afonso Rabelo Buzalaf; Rafael Rodrigues Lima
Journal:  Oxid Med Cell Longev       Date:  2017-07-24       Impact factor: 6.543

Review 7.  Radiation therapy and serum salivary amylase in head and neck cancer.

Authors:  Francesca De Felice; Mario Tombolini; Angela Musella; Francesco Marampon; Vincenzo Tombolini; Daniela Musio
Journal:  Oncotarget       Date:  2017-06-28

Review 8.  The Effect of Digestion and Digestibility on Allergenicity of Food.

Authors:  Isabella Pali-Schöll; Eva Untersmayr; Martina Klems; Erika Jensen-Jarolim
Journal:  Nutrients       Date:  2018-08-21       Impact factor: 5.717

Review 9.  Influence of In Vitro Digestion on Composition, Bioaccessibility and Antioxidant Activity of Food Polyphenols-A Non-Systematic Review.

Authors:  Karolina Wojtunik-Kulesza; Anna Oniszczuk; Tomasz Oniszczuk; Maciej Combrzyński; Dominika Nowakowska; Arkadiusz Matwijczuk
Journal:  Nutrients       Date:  2020-05-13       Impact factor: 5.717

10.  Copy Number Variation of the Salivary Amylase Gene and Glucose Metabolism in Healthy Young Japanese Women.

Authors:  Ryoko Higuchi; Taizo Iwane; Ayaka Iida; Kei Nakajima
Journal:  J Clin Med Res       Date:  2020-03-02
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