Chung-Lieh Hung1, Alexandra Gonçalves2, Yu-Jun Lai3, Yau-Huei Lai4, Kuo-Tzu Sung4, Chi-In Lo4, Chuan-Chuan Liu5, Jen-Yuan Kuo6, Charles Jia-Yin Hou6, Tze-Fan Chao7, Bernard E Bulwer8, Shing-Jong Lin9, Hung-I Yeh10, Carolyn S P Lam11. 1. Division of Cardiology, Departments of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan; Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; MacKay Junior College of Medicine, Nursing and Management, New Taipei City, Taiwan; Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan. 2. University of Porto Medical School, Porto, Portugal; Brigham and Women's Hospital, Boston, Massachusetts. 3. Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan; MacKay Junior College of Medicine, Nursing and Management, New Taipei City, Taiwan. 4. Division of Cardiology, Departments of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan; Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; MacKay Junior College of Medicine, Nursing and Management, New Taipei City, Taiwan. 5. Health Evaluation Center, Mackay Memorial Hospital, Taipei, Taiwan; Graduate Institute of Health Care Organization Administration, College of Public Health National Taiwan University, Taipei, Taiwan; Department of Medical Technology, Yuanpei University of Science and Technology, Hsinchu, Taiwan. 6. Division of Cardiology, Departments of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan; Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan. 7. Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan. 8. Brigham and Women's Hospital, Boston, Massachusetts. 9. Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan; Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address: sjlin@vghtpe.gov.tw. 10. Division of Cardiology, Departments of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan; Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; MacKay Junior College of Medicine, Nursing and Management, New Taipei City, Taiwan. Electronic address: hiyeh@ms1.mmh.org.tw. 11. National Heart Centre Singapore and Duke-National University of Singapore, Singapore.
Abstract
BACKGROUND: The effects of light to moderate alcohol consumption on cardiac mechanics remain poorly understood. The aim of this study was to investigate the dose-response relationship between alcohol consumption and left ventricular (LV) and left atrial (LA) function using myocardial deformation. METHODS: In total 3,946 asymptomatic participants (mean age, 49.7 ± 10.7 years; 65% men) were consecutively studied using comprehensive echocardiography and two-dimensional speckle-tracking in a cross-sectional, retrospective manner. Global LV longitudinal and circumferential strain and LA strain were assessed and related to habitual alcohol consumption pattern (fewer than one, one to six, or more than six drinks per week) before and after propensity matching. RESULTS: With increasing weekly alcohol consumption, participants displayed greater LV eccentric remodeling, impaired diastolic function, and more attenuated global longitudinal strain, LA strain (adjusted coefficients, -1.07 [95% CI, -1.95 to -0.19] and -3.73 [95% CI, -5.36 to -2.11]), and early diastolic strain rates (adjusted coefficients, 0.07 [95% CI, 0.03-0.11] and 0.33 [95% CI, 0.24-0.42]) for one to six and more than six drinks per week, respectively (P < .05 for all) in a dose-response manner. Participants with recent alcohol abstinence displayed cardiac mechanics intermediate between those of nondrinkers and current drinkers. After propensity matching (n = 1,140), participants currently consuming more than one drink per week continued to have significantly attenuated global longitudinal strain and all LA mechanics compared with those consuming fewer than one drink per week (P < .05 for all). CONCLUSIONS: Habitual alcohol consumption, even at light to moderate doses, is associated with both reduced LV and LA mechanics in a dose-dependent manner. Whether such observations are reversible or related to future atrial fibrillation deserves further study.
BACKGROUND: The effects of light to moderate alcohol consumption on cardiac mechanics remain poorly understood. The aim of this study was to investigate the dose-response relationship between alcohol consumption and left ventricular (LV) and left atrial (LA) function using myocardial deformation. METHODS: In total 3,946 asymptomatic participants (mean age, 49.7 ± 10.7 years; 65% men) were consecutively studied using comprehensive echocardiography and two-dimensional speckle-tracking in a cross-sectional, retrospective manner. Global LV longitudinal and circumferential strain and LA strain were assessed and related to habitual alcohol consumption pattern (fewer than one, one to six, or more than six drinks per week) before and after propensity matching. RESULTS: With increasing weekly alcohol consumption, participants displayed greater LV eccentric remodeling, impaired diastolic function, and more attenuated global longitudinal strain, LA strain (adjusted coefficients, -1.07 [95% CI, -1.95 to -0.19] and -3.73 [95% CI, -5.36 to -2.11]), and early diastolic strain rates (adjusted coefficients, 0.07 [95% CI, 0.03-0.11] and 0.33 [95% CI, 0.24-0.42]) for one to six and more than six drinks per week, respectively (P < .05 for all) in a dose-response manner. Participants with recent alcohol abstinence displayed cardiac mechanics intermediate between those of nondrinkers and current drinkers. After propensity matching (n = 1,140), participants currently consuming more than one drink per week continued to have significantly attenuated global longitudinal strain and all LA mechanics compared with those consuming fewer than one drink per week (P < .05 for all). CONCLUSIONS:Habitual alcohol consumption, even at light to moderate doses, is associated with both reduced LV and LA mechanics in a dose-dependent manner. Whether such observations are reversible or related to future atrial fibrillation deserves further study.
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