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Literature DB >> 27639628

Revisiting the Immunoglobulin Intramolecular Signaling Hypothesis.

Abstract

A generation ago, the immunoglobulin intramolecular signaling, or allosteric, hypothesis was abandoned in favor of the associative hypothesis, which posited that Fc receptor crosslinking produced the increased affinity of antigen-antibody complexes. This essay argues that there is sufficient evidence to resuscitate the allosteric hypothesis, at least for some antibodies.

Entities: Chemical Disease Gene Species

Keywords: allosteric model; antibody; associative model; immunoglobulin; intramolecular signaling

Mesh：

Substances：

Year: 2016 PMID： 27639628 PMCID： PMC5287420 DOI： 10.1016/j.it.2016.08.014

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

12 in total

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Authors: Masayuki Oda; Haruo Kozono; Hisayuki Morii; Takachika Azuma
Journal: Int Immunol Date: 2003-03 Impact factor: 4.823

9. A requirement for FcγR in antibody-mediated bacterial toxin neutralization.

Authors: Nareen Abboud; Siu-Kei Chow; Carolyn Saylor; Alena Janda; Jeffery V Ravetch; Matthew D Scharff; Arturo Casadevall
Journal: J Exp Med Date: 2010-10-04 Impact factor: 14.307

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Authors: Alena Janda; Anthony Bowen; Neil S Greenspan; Arturo Casadevall
Journal: Front Microbiol Date: 2016-02-04 Impact factor: 5.640

7 in total

Review 1. B cells, plasma cells and antibody repertoires in the tumour microenvironment.

Authors: George V Sharonov; Ekaterina O Serebrovskaya; Diana V Yuzhakova; Olga V Britanova; Dmitriy M Chudakov
Journal: Nat Rev Immunol Date: 2020-01-27 Impact factor: 53.106

2. A Monoclonal Antibody to Cryptococcus neoformans Glucuronoxylomannan Manifests Hydrolytic Activity for Both Peptides and Polysaccharides.

Authors: Anthony Bowen; Maggie P Wear; Radames J B Cordero; Stefan Oscarson; Arturo Casadevall
Journal: J Biol Chem Date: 2016-11-21 Impact factor: 5.157

3. CH2 Domain of Mouse IgG3 Governs Antibody Oligomerization, Increases Functional Affinity to Multivalent Antigens and Enhances Hemagglutination.

Authors: Tomasz Klaus; Joanna Bereta
Journal: Front Immunol Date: 2018-05-23 Impact factor: 7.561

Review 4. IgG cooperativity - Is there allostery? Implications for antibody functions and therapeutic antibody development.

Authors: Danlin Yang; Rachel Kroe-Barrett; Sanjaya Singh; Christopher J Roberts; Thomas M Laue
Journal: MAbs Date: 2017-08-16 Impact factor: 5.857